90213-73-3

Upstream product

• 70613-79-5 2,3,5-tri-O-benzyl-D-arabinofuranosyl bromide 
• 84955-31-7 4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine 
• 52522-49-3 2,3,5-tri-O-benzyl-1-(4-nitrobenzoyloxy)-D-arabinofuranose 
• 70384-51-9 Tris(3,6-dioxaheptyl)amine 

Relevant academic research and scientific papers

NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYERMASE

The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.

7-(β-D-Arabinofuranosyl)-2,4-dichloro-7H-pyrrolopyrimidine - Synthesis, Selective Displacement of Halogen, and Influence of Glyconic Protecting Groups on the Reactivity of the Aglycone

Selective N-7 glycosylation of 2,4-dichloro-7H-pyrrolopyrimidine (1a) with the arabinohalogenose 5 has been achieved yielding the β-anomer 7a in 67percent yield.Debenzylation with boron trichloride results in the formation of the 2,4-dichloronucleo