902131-29-7 Usage
Methyl ester derivative
4-amino-1H-benzimidazole-1-carboxylic acid The compound is derived from 4-amino-1H-benzimidazole-1-carboxylic acid by attaching a methyl ester group.
Pharmaceutical industry use
Building block for synthesis The compound serves as a starting material for creating various pharmaceutical compounds.
Applications
Antiviral and anticancer drugs It is used in the development of drugs that target viruses and cancer cells.
Synthesis of fluorescent dyes and imaging agents
The compound is utilized in creating dyes and agents that can be used for visualizing and imaging biological processes.
Potential use
New materials development It may be used in the creation of innovative materials for various applications.
Reagent in chemical research and development
The compound serves as a useful tool in chemical research, aiding in the discovery and development of new compounds and processes.
Versatility
Important applications in various fields Due to its unique properties and potential uses, 1H-Benzimidazole-1-carboxylic acid, 4-amino-, methyl ester is a valuable compound in multiple industries and research areas.
Check Digit Verification of cas no
The CAS Registry Mumber 902131-29-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,0,2,1,3 and 1 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 902131-29:
(8*9)+(7*0)+(6*2)+(5*1)+(4*3)+(3*1)+(2*2)+(1*9)=117
117 % 10 = 7
So 902131-29-7 is a valid CAS Registry Number.
902131-29-7Relevant academic research and scientific papers
Drizin, Irene,Gomtsyan, Arthur,Bayburt, Erol K.,Schmidt, Robert G.,Zheng, Guo Zhu,Perner, Richard J.,DiDomenico, Stanley,Koenig, John R.,Turner, Sean C.,Jinkerson, Tammie K.,Brown, Brian S.,Keddy, Ryan G.,McDonald, Heath A.,Honore, Prisca,Wismer, Carol T.,Marsh, Kennan C.,Wetter, Jill M.,Polakowski, James S.,Segreti, Jason A.,Jarvis, Michael F.,Faltynek, Connie R.,Lee, Chih-Hung
, p. 4740 - 4749 (2006)
Novel 5,6-fused heteroaromatic ureas were synthesized and evaluated for their activity as TRPV1 antagonists. It was found that 4-aminoindoles and indazoles are the preferential cores for the attachment of ureas. Bulky electron-withdrawing groups in the para-position of the aromatic ring of the urea substituents imparted the best in vitro potency at TRPV1. The most potent derivatives were assessed in in vivo inflammatory and neuropathic pain models. Compound 46, containing the indazole core and a 3,4-dichlorophenyl group appended to it via a urea linker, demonstrated in vivo analgesic activity upon oral administration. This derivative also showed selectivity versus other receptors in the CEREP screen and exhibited acceptable cardiovascular safety at levels exceeding the therapeutic dose.
