902134-01-4

Usage

Chemical classification

1-phenyl-4-pyridin-4-yl-1,2-dihydro-3H-pyrazol-3-one is a heterocyclic compound.

Derivative

It is a derivative of pyrazolone.

Structural components

Contains a phenyl group, a pyridine ring, and a pyrazolone ring.

Pharmaceutical application

Used for its potential pharmacological properties.

Medicinal effects

Exhibits anti-inflammatory and analgesic effects.

Research potential

Being studied for the treatment of various diseases and conditions.

Importance in medicinal chemistry

Its unique structure and properties make it valuable for research and development.

Upstream product

• 100394-64-7 [4]pyridyl-acetic acid-(N'-phenyl-hydrazide) 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 902134-00-3 1-phenyl-4-piperidin-4-yl-1,2-dihydro-3H-pyrazol-3-one 

Relevant academic research and scientific papers

BIARYL KETONE-SUBSTITUTED PIPERIDINES

Biaryl ketone-substituted piperidines of the following Formulas are provided:, and in which the variables are as described herein. Such compounds may be used to modulate calcitonin gene-related peptide (CGRP) receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions responsive to CGRP modulation in humans, domesticated companion animals and livestock animals, including headache such as migraine. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such compounds for receptor localization studies and various in vitro assays.

AMIDE-SUBSTITUTED ARYL PIPERIDINES

Amide-substituted aryl piperidines derivatives of the following Formulas are provided:(Formulas), in which the variables are as described herein. Such compounds may be used to modulate calcitonin gene-related peptide (CGRP) receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions responsive to CGRP modulation in humans, domesticated companion animals and livestock animals, including headache, such as migraine. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such compounds for receptor localization studies and various in vitro assays.

CGRP RECEPTOR ANTAGONISTS

Compounds of Formula I: (where variables R1, R2, R3, R7, G, J, Q, T, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache, and pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.