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N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl, also known as AT7519, is an ATP-competitive inhibitor of cyclin-dependent kinases (Cdks) with varying IC50 values for different Cdk subtypes. It is particularly potent against Cdk1, 2, 4, 5, 6, and 9, and less potent against Cdk3 and Cdk7. AT7519 is inactive against non-Cdk kinases except for GSK3β. N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl demonstrates antiproliferative activity against a wide range of human tumor cell lines, inhibiting cell cycle progression and inducing apoptosis. It also prevents tumor growth in human tumor xenograft models and induces activation of GSK3β by down-regulating GSK3β phosphorylation, contributing to AT7519-induced apoptosis.

902135-91-5

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902135-91-5 Usage

Uses

Used in Pharmaceutical Industry:
N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl is used as a cyclin-dependent kinase inhibitor for the structure-based design of CDK2 inhibitors. It is employed in the development of potential anticancer drugs, targeting the cell cycle and inducing apoptosis in various human tumor cell lines.
Used in Cancer Research:
N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl is used as a research tool in cancer research to study the role of cyclin-dependent kinases in tumor growth and progression. It helps in understanding the mechanisms of action and potential therapeutic applications of CDK inhibitors in cancer treatment.

Check Digit Verification of cas no

The CAS Registry Mumber 902135-91-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,0,2,1,3 and 5 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 902135-91:
(8*9)+(7*0)+(6*2)+(5*1)+(4*3)+(3*5)+(2*9)+(1*1)=135
135 % 10 = 5
So 902135-91-5 is a valid CAS Registry Number.
InChI:InChI=1S/C16H17Cl2N5O2.ClH/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9;/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24);1H

902135-91-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-[(2,6-dichlorobenzoyl)amino]-N-piperidin-4-yl-1H-pyrazole-5-carboxamide,hydrochloride

1.2 Other means of identification

Product number -
Other names QCR-194

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:902135-91-5 SDS

902135-91-5Upstream product

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