902151-17-1Relevant academic research and scientific papers
Lipase-Induced Oxidative Furan Rearrangements
Blume, Fabian,Sprengart, Petra,Deska, Jan
, p. 1293 - 1296 (2018/01/27)
Lipase B from Candida antarctica catalyzes the oxidative ring expansion of furfuryl alcohols using aqueous hydrogen peroxide to yield functionalized pyranones under mild conditions. The method further allows for the preparation of corresponding piperidinone derivatives by enzymatic rearrangement of N-protected furfurylamines.
Novel γ-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates
Takahashi, Yasuko,Fuwa, Haruhiko,Kaneko, Akane,Sasaki, Makoto,Yokoshima, Satoshi,Koizumi, Hifumi,Takebe, Tohru,Kan, Toshiyuki,Iwatsubo, Takeshi,Tomita, Taisuke,Natsugari, Hideaki,Fukuyama, Tohru
, p. 3813 - 3816 (2007/10/03)
Screening of our in-house compound library comprised of intermediates of natural product synthesis projects resulted in discovering two novel γ-secretase inhibitors, which coincidently had similar moieties, that is, cyclohexenone and two aryl groups arran
