2,5-dihydro-3-methyl-2,5-dioxo-1H-pyrrole-1-propanoic acid, commonly known as acivicin, is a naturally-occurring antibiotic that functions as a potent inhibitor of gamma-glutamyl transferase. It is a derivative of the amino acid glutamate and structurally akin to L-serine. Acivicin has garnered attention for its potential anti-cancer, anti-viral, and anti-fibrotic properties, primarily due to its ability to inhibit the biosynthesis of glutathione, a crucial cellular antioxidant.
90222-78-9
Post Buying Request-
-
Basic information
- Product Name: 2,5-dihydro-3-methyl-2,5-dioxo-1H-pyrrole-1-propanoic acid
- Synonyms: 2,5-dihydro-3-methyl-2,5-dioxo-1H-pyrrole-1-propanoic acid
- CAS NO:90222-78-9
- Molecular Formula:
- Molecular Weight: 0
- EINECS: N/A
- Product Categories: N/A
-
Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: N/A
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: 2,5-dihydro-3-methyl-2,5-dioxo-1H-pyrrole-1-propanoic acid(CAS DataBase Reference)
- NIST Chemistry Reference: 2,5-dihydro-3-methyl-2,5-dioxo-1H-pyrrole-1-propanoic acid(90222-78-9)
- EPA Substance Registry System: 2,5-dihydro-3-methyl-2,5-dioxo-1H-pyrrole-1-propanoic acid(90222-78-9)
-
Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 90222-78-9(Hazardous Substances Data)
90222-78-9 Suppliers
Recommended suppliers
90222-78-9 Usage
Uses
Used in Cancer Chemotherapy:Acivicin is utilized as a chemotherapeutic agent, targeting the biosynthesis of glutathione, which is vital for cellular protection. By inhibiting this process, acivicin enhances the susceptibility of cancer cells to the cytotoxic effects of other chemotherapeutic agents, thereby contributing to the treatment of various malignancies.
Used in Treatment of Liver Diseases:
Given its impact on glutathione biosynthesis, acivicin has been investigated for its potential in managing liver diseases. The modulation of glutathione levels can influence the progression of liver pathologies, making acivicin a candidate for therapeutic intervention in hepatic conditions.
However, it is important to note that the clinical application of acivicin is constrained by its high toxicity and the narrow therapeutic window it presents, necessitating careful consideration in its use and dosage.
Check Digit Verification of cas no
The CAS Registry Mumber 90222-78-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,0,2,2 and 2 respectively; the second part has 2 digits, 7 and 8 respectively.Calculate Digit Verification of CAS Registry Number 90222-78:
(7*9)+(6*0)+(5*2)+(4*2)+(3*2)+(2*7)+(1*8)=109
109 % 10 = 9
So 90222-78-9 is a valid CAS Registry Number.
90222-78-9Upstream product
90222-78-9Downstream Products
Post a RFQ
1
What can I do for you?
Get Best Price
Get Best Price for 90222-78-9
2,5-dihydro-3-methyl-2,5-dioxo-1H-pyrrole-1-propanoic acid
