90222-81-4

Usage

Uses

Used in Chemical Synthesis:
2,3-Dihydro-benzo[1,4]dioxine-6-sulfonic acid amide is used as a reagent in chemical reactions for its ability to participate in various organic synthesis processes. Its unique structure allows it to be a versatile component in the creation of more complex molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2,3-Dihydro-benzo[1,4]dioxine-6-sulfonic acid amide is used as a building block for the development of new drugs. Its specific properties may contribute to the design of molecules with potential therapeutic effects, depending on the context of the research.
Used in Materials Science:
2,3-Dihydro-benzo[1,4]dioxine-6-sulfonic acid amide is employed in materials science for its potential to contribute to the development of new materials with specialized properties. Its structural features may be leveraged to create materials with unique characteristics for various applications.

InChI:InChI=1/C8H9NO4S/c9-14(10,11)6-1-2-7-8(5-6)13-4-3-12-7/h1-2,5H,3-4H2,(H2,9,10,11)

Upstream product

• 164014-95-3 2.3-dihydro-1,4-benzodioxin-6-ylboronic acid 

Downstream Products

• 112894-51-6 N-{[(4-Chlorophenyl)amino]carbonyl}-2,3-dihydro-1,4-benzodioxin-6-sulfonamide 

Relevant academic research and scientific papers

Palladium(II)-Catalyzed Synthesis of Sulfinates from Boronic Acids and DABSO: A Redox-Neutral, Phosphine-Free Transformation

A redox-neutral palladium(II)-catalyzed conversion of aryl, heteroaryl, and alkenyl boronic acids into sulfinate intermediates, and onwards to sulfones and sulfonamides, has been realized. A simple Pd(OAc)2 catalyst, in combination with the sulfur dioxide surrogate 1,4-diazabicyclo[2.2.2]octane bis(sulfur dioxide) (DABSO), is sufficient to achieve rapid and high-yielding conversion of the boronic acids into the corresponding sulfinates. Addition of C- or N-based electrophiles then allows conversion into sulfones and sulfonamides, respectively, in a one-pot, two-step process.

Anti-tumor method and compounds

This invention provides certain N-[(phenyl)amino]carbonyl-bicyclicsulfonamide sulfonamide derivatives, their pharmaceutical formulations, and their use in the treatment of susceptible neoplasms in mammals.

Synthesis of bicyclic aromatic sulfonyl chlorides

A process for preparing bicyclic aromatic sulfonyl chlorides of the formula wherein, n is 1 or 2;, A is -O- or -CH2-; and, B is -O-, -CH2-, or -NCH3-;, provided at least one of A or B is -O-,which comprises reacting a compound of the formula with a Villsmeier reagent of the formula The bicyclic aromatic sulfonyl chlorides produced by the process can be used to prepare pharmaceutically useful sulfonylureas.