Chondroitinase ABC is an enzyme that specifically cleaves chondroitin sulfate, a type of glycosaminoglycan found in the extracellular matrix of tissues. It is derived from the bacterium Proteus vulgaris and has the ability to degrade chondroitin sulfate, which is involved in various biological processes, including cell signaling, cell adhesion, and axon growth inhibition.
9024-13-9
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Basic information
- Product Name: CHONDROITINASE ABC
- Synonyms: CHONDROITINASE ABC;CHONDROITIN ABC LYASE;EC 4.2.2.4;chondroitinase abc F. proteus vulgaris;Chondroitinase ABC from Proteus vulgaris;Chondroitinase ABC, Proteus vulgaris*Not available Japan*;Chondroitinase ABC, Recomb.;chondroitinase-abc bsa free
- CAS NO:9024-13-9
- Molecular Formula: NULL
- Molecular Weight: 0
- EINECS: 232-777-9
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /lyophilized powder
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: −20°C
- Solubility: 0.01% bovine serum albumin aqueous (BSA) solution: soluble
- CAS DataBase Reference: CHONDROITINASE ABC(CAS DataBase Reference)
- NIST Chemistry Reference: CHONDROITINASE ABC(9024-13-9)
- EPA Substance Registry System: CHONDROITINASE ABC(9024-13-9)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: 22-24/25
- WGK Germany: 3
- RTECS:
- F: 10-21
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 9024-13-9(Hazardous Substances Data)
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9024-13-9 Usage
Uses
Used in Neuroscience Research:Chondroitinase ABC is used as a research tool for studying the consequences of inducing acute, long-lasting changes in chondroitin sulfate proteoglycans using adult rat brain cells. It helps in understanding the role of chondroitin sulfate in neural development and regeneration.
Used in Tissue Engineering and Regenerative Medicine:
Chondroitinase ABC is used as a digestion enzyme for digesting glycosaminoglycan chains in proteoglycans during the construction and expression of a recombinant versican gene in mammalian systems. It aids in the development of engineered tissues and the study of cell-matrix interactions.
Used in Cartilage and Connective Tissue Research:
Chondroitinase ABC is used as a digestion enzyme for digesting chondroitin sulfate in proteoglycan complexes, which are essential components of cartilage and connective tissues. This helps in studying the structure and function of these tissues and their role in various diseases.
Used in Osteoarthritis and Joint Disease Research:
Chondroitinase ABC is used as a therapeutic agent for the removal of glycan chains from aggrecan, a major proteoglycan in cartilage. This eliminates the axon growth-inhibitory effect of aggrecan, which is implicated in the progression of osteoarthritis and other joint diseases.
Used in Cell Culture and Tissue Analysis:
Chondroitinase ABC is used as a digestion enzyme for digesting glycosaminoglycans, such as chondroitin/dermatan sulfate, in keratocyte cell cultures obtained from fresh bovine corneal stroma. This allows for the quantitation and analysis of these glycosaminoglycans in various cell culture and tissue samples.
Biochem/physiol Actions
Chondroitinase ABC catalyzes the eliminative degradation of polysaccharides containing (1-4)-β-D-hexosaminyl and (1-3)-β-D-glucuronosyl (or (1-3)-α-L-iduronosyl) linkages to disaccharides containing 4-deoxy-β-D-gluc-4-enuronosyl groups. It acts on chondroitin 4-sulfate, chondroitin 6-sulfate, and dermatan sulfate. However, it acts slowly on hyaluronate. The molecular weight is approximately 120 kDa with 2 non-identical subunits of molecular masses 86 kDa and 32 kDa. The pH optimum is 8.0 with chondroitin sulfate and 6.8 with hyaluronic acid. The optimal temperature is 37 °C. 1 mM Zn2+ acts as an inhibitor, while 0.05 M acetate is an activator of the enzyme.Check Digit Verification of cas no
The CAS Registry Mumber 9024-13-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,2 and 4 respectively; the second part has 2 digits, 1 and 3 respectively.Calculate Digit Verification of CAS Registry Number 9024-13:
(6*9)+(5*0)+(4*2)+(3*4)+(2*1)+(1*3)=79
79 % 10 = 9
So 9024-13-9 is a valid CAS Registry Number.
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9024-13-9Downstream Products
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CHONDROITINASE ABC
