Aconitase, also known as citrate hydro-lyase, is an enzyme that plays a crucial role in the citric acid cycle (also known as the Krebs cycle or TCA cycle). It catalyzes the isomerization of citrate to isocitrate by converting cis-aconitate, a key intermediate in the cycle. Aconitase possesses iron-sulfur clusters and is sensitive to oxidative stress, making it a valuable target for studying cellular responses to oxidative stress and iron homeostasis.
Source:
Aconitase is found in various organisms, including bacteria, archaea, and eukaryotes, and is involved in the metabolic pathways of these organisms.
Production Methods:
Aconitase is produced through the expression of the aconitase gene in the respective organisms. The gene is then isolated and cloned into suitable expression vectors for recombinant protein production in host cells, such as bacteria or yeast.
Source:
Aconitase is found in various organisms, including bacteria, archaea, and eukaryotes, and is involved in the metabolic pathways of these organisms.
Production Methods:
Aconitase is produced through the expression of the aconitase gene in the respective organisms. The gene is then isolated and cloned into suitable expression vectors for recombinant protein production in host cells, such as bacteria or yeast.
9024-25-3
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Basic information
- Product Name: ACONITASE
- Synonyms: ACONITASE;ACONITATE HYDRATASE;EC 4.2.1.3;CITRATE [ISOCITRATE] HYDROLYASE;aconitase from porcine heart;ACONITASE, FROM PIG HEART;Aconitate hydratase, Citrate (isocitrate) hydrolyase;Aconitase, Citrate (isocitrate) hydro-lyase
- CAS NO:9024-25-3
- Molecular Formula:
- Molecular Weight: 0
- EINECS: N/A
- Product Categories: enzyme
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: −20°C
- Solubility: N/A
- CAS DataBase Reference: ACONITASE(CAS DataBase Reference)
- NIST Chemistry Reference: ACONITASE(9024-25-3)
- EPA Substance Registry System: ACONITASE(9024-25-3)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: 22-24/25
- WGK Germany: 3
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 9024-25-3(Hazardous Substances Data)
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9024-25-3 Usage
Uses
Used in Diabetes Research:Aconitase is used as a research tool for studying the molecular mechanisms underlying diabetes and its complications. The enzyme's sensitivity to oxidative stress makes it a valuable indicator of cellular redox status, which is often disrupted in diabetes.
Used in Structural Conservation Studies:
Aconitase is used as a model system for investigating the structural conservation between iron-responsive element binding proteins (IRE-BP) and isomerases. This research helps to understand the evolutionary relationships and functional similarities between these proteins, providing insights into their roles in cellular processes.
Used in Oxidative Stress Research:
Aconitase is employed as a biomarker for oxidative stress in various biological systems. Its sensitivity to reactive oxygen species (ROS) allows researchers to monitor and study the effects of oxidative stress on cellular function and homeostasis.
Used in Iron Homeostasis Studies:
Aconitase is used as a tool for investigating iron homeostasis in cells. The enzyme's iron-sulfur clusters are essential for its activity, and changes in aconitase activity can be used to assess cellular iron levels and the mechanisms regulating iron uptake and storage.
Biochem/physiol Actions
Aconitase catalyses the stereo-specific isomerization of citrate to isocitrate via cis-aconitate in the tricarboxylic acid cycle. Aconitase is inhibited by cyanide, sulfide and copper and mercury at low concentrations. It is competitively inhibited by trans-aconitate. Aconitase contains an internal Fe-S cluster which is responsible for its activity.Check Digit Verification of cas no
The CAS Registry Mumber 9024-25-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,2 and 4 respectively; the second part has 2 digits, 2 and 5 respectively.Calculate Digit Verification of CAS Registry Number 9024-25:
(6*9)+(5*0)+(4*2)+(3*4)+(2*2)+(1*5)=83
83 % 10 = 3
So 9024-25-3 is a valid CAS Registry Number.
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9024-25-3Downstream Products
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