9025-10-9

Basic information

• Product Name: 5'-ADENYLIC ACID DEAMINASE
• Synonyms: 5'-ADENYLIC ACID DEAMINASE;DEAMINASE FROM ASPERGILLUS MELLEUS;5'-ADENYLIC ACID DEAMINASE FROMASPERGILL US SPECIES;5'-adenylic acid deaminase from aspergillus sp.;DEAMIZYME5000;5ADENYLICDEAMINASE;DN-50000;Deaminase, adenylate
• CAS NO: 9025-10-9
• Molecular Weight: 0
• Product Categories: General Metabolic Enzymes;Metabolomics;Nucleotide Metabolism
• Mol File: 9025-10-9.mol
• Article Data: 0

Chemical Properties

• Appearance: slightly beige/lyophilized powder
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5'-ADENYLIC ACID DEAMINASE(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-ADENYLIC ACID DEAMINASE(9025-10-9)
• EPA Substance Registry System: 5'-ADENYLIC ACID DEAMINASE(9025-10-9)

Safety Data

• WGK Germany: 1
• F: 3-10
• Hazardous Substances Data: 9025-10-9(Hazardous Substances Data)

Usage

Description

5'-Adenylic acid deaminase, also known as adenosine monophosphate deaminase, is an enzyme that plays a pivotal role in the biosynthesis of purine nucleotides, which are essential building blocks for DNA and RNA. It catalyzes the conversion of adenosine monophosphate (AMP) to inosine monophosphate (IMP) by removing the amine group from the adenine base. This enzymatic reaction is crucial for the regulation of purine nucleotide levels in the cell, and its dysregulation has been linked to various diseases, including metabolic disorders and muscular dystrophy, underscoring its importance in cellular metabolism and homeostasis.

Uses

Used in Pharmaceutical Industry:
5'-Adenylic acid deaminase is used as a therapeutic target for the treatment of various diseases associated with its dysregulation. Its modulation can help in managing metabolic disorders and muscular dystrophy by maintaining the balance of purine nucleotide levels in the cell.
Used in Research and Development:
5'-Adenylic acid deaminase serves as a valuable tool in research for understanding the mechanisms of purine nucleotide biosynthesis and its role in cellular metabolism. Studying the enzyme's function and regulation can provide insights into the development of novel therapeutic strategies for diseases related to its dysregulation.
Used in Diagnostic Applications:
Measurement of 5'-adenylic acid deaminase activity can be utilized as a diagnostic tool to assess the metabolic status of cells and identify potential imbalances in purine nucleotide levels. This can aid in the early detection and monitoring of diseases associated with the enzyme's dysregulation.
Used in Drug Development:
Understanding the structure and function of 5'-adenylic acid deaminase can facilitate the design and development of drugs that target this enzyme. Such drugs can potentially modulate its activity to treat diseases related to its dysregulation, offering new therapeutic options for patients.
Used in Biochemical Education:
5'-Adenylic acid deaminase serves as an important example in biochemical education to illustrate the role of enzymes in metabolic pathways and the consequences of their dysregulation. Studying this enzyme can help students grasp the concepts of enzyme kinetics, metabolic regulation, and the molecular basis of diseases.