902525-97-7

Upstream product

• 498-02-2 1-(3-methoxy-4-hydroxyphenyl)ethanone 
• 100-44-7 benzyl chloride 
• 1835-11-6 4-benzyloxy-3-methoxyacetophenone 
• 902525-96-6 2-bromo-1-(4-(benzyloxy)-3-methoxyphenyl)ethanol 
• 137886-47-6 2-(4-(benzyloxy)-3-methoxyphenyl)oxirane 
• 1835-12-7 3-methoxy-4-benzyloxy-α-bromoacetophenone 

Relevant academic research and scientific papers

New chiral building blocks from acetovanillone using lipase A and B from Candida antarctica

Acetovanillone has been used as the starting material for the synthesis of a series of secondary alcohols, which were resolved by lipase catalyzed esterification. 1-(4-Benzyloxy-3-methoxyphenyl)ethanol was efficiently resolved using immobilized lipase B from Candida antarctica (Novozym 435, CAL-B), whereas immobilized lipase A from C. antarctica (Novozym 735, CAL-A) was the lipase of choice for the resolution of the corresponding 2-bromo- and 2-chloro-derivatives. The enantioenriched alcohols are new building blocks for potential use in the synthesis of bioactive compounds.