EC 3.5.4.4, also known as adenosine deaminase, is an enzyme that catalyzes the deamination of adenosine and deoxyadenosine to inosine and deoxyinosine, respectively. It plays a crucial role in the regulation of purine metabolism and has potential therapeutic applications in various diseases. Adenosine deaminase is a white amorphous powder with a molecular weight of 32.5-33 kDa and an isoelectric point of 4.85.
9026-93-1
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Basic information
- Product Name: EC 3.5.4.4
- Synonyms: fromcalfintestinalmucosabiochemika,in50%glycerol,0.01mkh2po4,ph6.0solution(clear),pal;Adenosinedeaminasebovinespleen;adenosine deaminase from bovine spleen;Adenosine Deaminase Screening Kit;ADENOSINE DEAMINASE, FROM CALF SPLEEN;Deoxyadenosine deaminase;Adenosine deaminase [>=150 units/mg];AdenosinedeaMinaseTypeII
- CAS NO:9026-93-1
- Molecular Formula:
- Molecular Weight: 0
- EINECS: 232-817-5
- Product Categories: Hydrolases;Specialty Enzymes
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: pale yellow/solution (clear)
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: 2-8°C
- Solubility: N/A
- CAS DataBase Reference: EC 3.5.4.4(CAS DataBase Reference)
- NIST Chemistry Reference: EC 3.5.4.4(9026-93-1)
- EPA Substance Registry System: EC 3.5.4.4(9026-93-1)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: 23-24/25
- WGK Germany: 3
- RTECS:
- F: 10
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 9026-93-1(Hazardous Substances Data)
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9026-93-1 Usage
Uses
Used in Molecular Biology Assays:EC 3.5.4.4 is used as a tool enzyme in various molecular biology assays, such as glycerol release assays, to study the activity and function of the enzyme in different biological processes.
Used in Treatment of Combined Immunodeficiency Disease:
Adenosine deaminase is a potential target for the treatment of combined immunodeficiency disease, a genetic disorder that affects the immune system. Inhibition of adenosine deaminase activity can help improve the immune function in patients with this disease.
Used in Pre-treatment of Primary Kupffer Cells:
EC 3.5.4.4 has been used to pre-treat primary Kupffer cells, which are liver-specific immune cells, to study their role in immune responses and liver diseases. This application helps researchers understand the interaction between adenosine deaminase and Kupffer cells in the context of liver pathophysiology.
Biochem/physiol Actions
Adenosine deaminase is a purine catabolic enzyme which catalyzes the deamination of adenosine and 2′-deoxyadenosine with approximately equal specificity. It is ubiquitous in mammalian tissue, and deficiency in adenosine deaminase has been associated with severe combined immunodeficiency disease.Check Digit Verification of cas no
The CAS Registry Mumber 9026-93-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,2 and 6 respectively; the second part has 2 digits, 9 and 3 respectively.Calculate Digit Verification of CAS Registry Number 9026-93:
(6*9)+(5*0)+(4*2)+(3*6)+(2*9)+(1*3)=101
101 % 10 = 1
So 9026-93-1 is a valid CAS Registry Number.
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EC 3.5.4.4
