3-Deoxy-D-manno-octulosonate aldolase (KDO8P synthase) is a crucial enzyme involved in the biosynthesis of 3-deoxy-D-manno-octulosonate (KDO), a key component of the lipopolysaccharide (LPS) found in the outer membrane of Gram-negative bacteria. This enzyme catalyzes the reversible aldol condensation of pyruvate and phosphoenolpyruvate (PEP) to form KDO8P, which is then converted to KDO. The enzyme plays a significant role in bacterial cell wall synthesis and is considered a potential target for the development of new antibiotics, as its inhibition can disrupt bacterial growth and survival. Understanding the structure, function, and regulation of 3-deoxy-D-manno-octulosonate aldolase is essential for the design of novel antimicrobial agents targeting Gram-negative pathogens.
The CAS Registry Mumber 9026-95-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,2 and 6 respectively; the second part has 2 digits, 9 and 5 respectively. Calculate Digit Verification of CAS Registry Number 9026-95: (6*9)+(5*0)+(4*2)+(3*6)+(2*9)+(1*5)=103 103 % 10 = 3 So 9026-95-3 is a valid CAS Registry Number.
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