902771-07-7Relevant academic research and scientific papers
General and efficient indole syntheses based on catalytic amination reactions
Ackermann, Lutz
, p. 439 - 442 (2005)
(Chemical Equation Presented) Highly flexible and efficient syntheses of the indole backbone are presented starting from o-alkynylhaloarenes. These transformations proceed via a palladium- or a copper-catalyzed amination reaction and a subsequent cyclization reaction in good to excellent yields. Furthermore, a multicatalytic one-pot indole synthesis starting from o-chloroiodobenzene is viable using a single catalyst consisting of an N-heterocyclic carbene palladium complex and Cul.
2,3-Disubstituted benzofuran and indole by copper-mediated C-C bond extension reaction of 3-zinciobenzoheterole
Nakamura, Masaharu,Ilies, Laurean,Otsubo, Saika,Nakamura, Eiichi
, p. 2803 - 2805 (2007/10/03)
A metalative 5-endo-dig cyclization reaction of 2-ynylphenoles or anilines effected by BuLi and ZnCl2 produces 3-zinciobenzoheteroles in excellent yield. These intermediates have been transmetalated to the corresponding cuprates and allowed to react with electrophiles to produce a variety of 2,3-disubstituted benzofurans and indoles.
