902772-07-0

Basic information

• Product Name: Acetic acid, [[4-chloro-2-(trifluoroacetyl)phenyl]amino]oxo-, ethyl ester
• CAS NO: 902772-07-0
• Molecular Formula: C12H9ClF3NO4
• Molecular Weight: 323.656
• Mol File: 902772-07-0.mol

Chemical Properties

• CAS DataBase Reference: Acetic acid, [[4-chloro-2-(trifluoroacetyl)phenyl]amino]oxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, [[4-chloro-2-(trifluoroacetyl)phenyl]amino]oxo-, ethyl ester(902772-07-0)
• EPA Substance Registry System: Acetic acid, [[4-chloro-2-(trifluoroacetyl)phenyl]amino]oxo-, ethyl ester(902772-07-0)

Safety Data

• Hazardous Substances Data: 902772-07-0(Hazardous Substances Data)

Upstream product

• 4755-77-5 Ethyl oxalyl chloride 
• 154598-53-5 1-(2-amino-5-chloro-phenyl)-2,2,2-trifluoro-ethanone 

Downstream Products

• 902772-08-1 ethyl 5-chloro-3-(trifluoromethyl)-1H-indole-2-carboxylate 

Relevant articles and documents

En Route to 2-(Cyclobuten-1-yl)-3-(trifluoromethyl)-1H-indole

A six-step synthetic route from 4-chloro-2-methylaniline to 5-chloro-2-(cyclobut-1-en-1-yl)-3-(trifluoromethyl)-1H-indole (1) has been reported. Compound 1a is a key impurity of reverse transcriptase inhibitor efavirenz, an important anti-HIV/AIDS drug. Synthetic challenges, dead ends, and detours are discussed.

INDOLES USEFUL IN THE TREATMENT OF INFLAMATION

There is provided compounds of formula (I), Wherein T, Y, X1 , R1, R2, R3, R4 and R5 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a member of the MAPEG family is desired and/or required, and particularly in the treatment of inflammation.