902772-47-8Relevant academic research and scientific papers
New: N -(2-phenyl-4-oxo-1,3-thiazolidin-3-yl)-1,2-benzothiazole-3-carboxamides and acetamides as antimicrobial agents
Incerti, Matteo,Vicini, Paola,Geronikaki, Athina,Eleftheriou, Phaedra,Tsagkadouras, Athanasios,Zoumpoulakis, Panagiotis,Fotakis, Charalmpos,?iri?, Ana,Glamo?lija, Jasmina,Sokovi?, Marina
, p. 2142 - 2154 (2017)
A series of 21 novel N-[2-phenyl-4-oxo-1,3-thiazolidin-3-yl]-1,2-benzothiazole-3-carboxamides/acetamides (4a-4p) as well as a series of N′-(halophenylmethylidene)-1,2-benzothiazole-3-acetohydrazides (3h-3p) have been synthesized and evaluated for their antimicrobial activity against eight bacterial and eight fungal species, among them plant, animal and human pathogens and food contaminating species. All compounds appeared to be potent and the best activity was exhibited by compound 4d with MIC in the range of 10.7-21.4 μmol mL-1 × 10-2 and MBC of 21.4-40.2 μmol mL-1 × 10-2. The best antifungal activity was observed for compounds 4p and 3h. Elucidation of the relationship between the antimicrobial activity and molecular properties of the synthesized compounds was also performed. Synthetic intermediates were also tested with several exhibiting good antimicrobial activities. Docking studies for some compounds were performed.
Anti-HIV evaluation of benzo[d]isothiazole hydrazones
Vicini, Paola,Incerti, Matteo,La Colla, Paolo,Loddo, Roberta
scheme or table, p. 1801 - 1807 (2009/05/07)
The synthesis and the anti-HIV-1 activity of novel benzo[d]isothiazole hydrazones are reported. Target compounds tested in MT-4 cells cultures for their anti-HIV properties against wild type HIV-1 and HIV strains carrying clinically relevant mutations (EF
