EC 1.1.1.40, also known as malic dehydrogenase (MDH), is an enzyme that catalyzes the reversible oxidation of malate to oxaloacetate, playing a crucial role in various metabolic pathways. It exists in two isoforms within eukaryotic cells: one expressed in the mitochondria and involved in the TCA cycle, and one in the cytoplasm that converts malate from the mitochondria back into oxaloacetate.
9028-47-1
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Basic information
- Product Name: EC 1.1.1.40
- Synonyms: MALIC ENZYME;L-MALATE: NADP+ OXIDOREDUCTASE-[OXALACETATE-DECARBOXYLATING];EC 1.1.1.40;malate dehydrog. (oxalacetate-decarbo-xyl.);malic enzyme from chicken liver;Dehydrogenase, malate (oxalacetate-decarboxylating) (nicotinamide adenine dinucleotide phosphate);malic dehydrogenase (oxalacetate-decarboxylating) from chicken liver;malate dehydrogenase (oxalacetate-decarboxylating)
- CAS NO:9028-47-1
- Molecular Formula:
- Molecular Weight: 0
- EINECS: 232-834-8
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: 2-8°C
- Solubility: N/A
- CAS DataBase Reference: EC 1.1.1.40(CAS DataBase Reference)
- NIST Chemistry Reference: EC 1.1.1.40(9028-47-1)
- EPA Substance Registry System: EC 1.1.1.40(9028-47-1)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany: 3
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 9028-47-1(Hazardous Substances Data)
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9028-47-1 Usage
Uses
Used in Cofactor Regeneration:EC 1.1.1.40 is used as a cofactor for the regeneration of NADH in reductive processes, which is essential for maintaining the balance of reducing equivalents in the cell and supporting various metabolic reactions.
Used in Diagnostics:
Malic dehydrogenase has been utilized in diagnostics to assess the dietary manganese requirement of juvenile yellow catfish (Pelteobagrus fulvidraco) and its effects on whole body mineral composition and hepatic intermediary metabolism. This application aids in understanding the nutritional needs and metabolic health of the species.
Used in Animal Nutrition Research:
In the animal nutrition industry, EC 1.1.1.40 has been employed in a study to investigate the establishment and biological characterization of a fibroblast cell line from the Langshan chicken. This research contributes to the understanding of the chicken's cellular and metabolic responses, which can be valuable for improving animal health and productivity.
Used in Metabolic Pathway Studies:
Malic dehydrogenase is used in the study of metabolic pathways, particularly in the TCA cycle and the conversion of malate to oxaloacetate. This enzyme plays a vital role in understanding the regulation and function of these pathways, which can have implications in various fields such as medicine, biotechnology, and nutrition.
Biochem/physiol Actions
Expression of malic dehydrogenase in chicken liver is induced upon feeding and decreases in response to starvation.Check Digit Verification of cas no
The CAS Registry Mumber 9028-47-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,2 and 8 respectively; the second part has 2 digits, 4 and 7 respectively.Calculate Digit Verification of CAS Registry Number 9028-47:
(6*9)+(5*0)+(4*2)+(3*8)+(2*4)+(1*7)=101
101 % 10 = 1
So 9028-47-1 is a valid CAS Registry Number.
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EC 1.1.1.40
