Basic information

Product Name: EC 1.1.1.42
Synonyms: ICDH;ISOCITRIC DEHYDROGENASE (NADP);ISOCITRIC DEHYDROGENASE (NADP) TYPE I;ISOCITRIC DEHYDROGENASE (NADP) TYPE IV;ISOCITRATE DEHYDROGENASE;EC 1.1.1.42;EC 1.1.1.42 TYPE I;EC 1.1.1.42 TYPE IV
CAS NO:9028-48-2
Molecular Formula: NULL
Molecular Weight: 0
EINECS: 232-835-3
Product Categories: enzyme

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: yellow-brown/solution (clear)
Density: N/A
Refractive Index: N/A
Storage Temp.: 2-8°C
Solubility: N/A
CAS DataBase Reference: EC 1.1.1.42(CAS DataBase Reference)
NIST Chemistry Reference: EC 1.1.1.42(9028-48-2)
EPA Substance Registry System: EC 1.1.1.42(9028-48-2)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany: 3
RTECS:
F: 10
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 9028-48-2(Hazardous Substances Data)

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Usage
SDS
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9028-48-2 Usage

Uses

Used in Enzyme Kinetics Studies:
EC 1.1.1.42 is used as a subject for enzyme kinetics studies to understand the enzyme's catalytic activity and regulation.
Used in Inhibitor Screening:
EC 1.1.1.42 is used as a target for screening inhibitors to identify potential drugs that can modulate its activity.
Used in Selectivity Profiling:
EC 1.1.1.42 is used as a tool for selectivity profiling to determine the specificity of inhibitors and drugs for this enzyme.
Used in Biomarker Development:
EC 1.1.1.42 is used as a potential biomarker for the diagnosis and prognosis prediction of non-small cell lung cancer.
Used in Pharmaceutical Industry:
EC 1.1.1.42 is used as a target for drug development for the treatment of non-small cell lung cancer and other diseases associated with IDH1 mutations.

Biochem/physiol Actions

Isocitrate dehydrogenase 1 (IDH1) help in the oxidative carboxylation of isocitrate to α-ketoglutarate, that results in the formation of reduced nicotinamide adenine dinucleotide phosphate (NADPH). It participates in lipid metabolism and glucose sensing. Suppressing IDH1 in pancreatic islets affects the insulin secretion, induced by glucose and leads to increase in lactate production.

Check Digit Verification of cas no

The CAS Registry Mumber 9028-48-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,2 and 8 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 9028-48:
(6*9)+(5*0)+(4*2)+(3*8)+(2*4)+(1*8)=102
102 % 10 = 2
So 9028-48-2 is a valid CAS Registry Number.

9028-48-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name	Isocitric Dehydrogenase (NADP) from porcine heart

1.2 Other means of identification

Product number	-
Other names	-

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:9028-48-2 SDS

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