Aldehyde dehydrogenase is a group of enzymes that catalyze the oxidation of aldehydes to carboxylic acids in the human body. This family of enzymes is essential for the metabolism of alcohol, as it converts toxic acetaldehyde into acetic acid. Aldehyde dehydrogenase also plays a role in the breakdown of neurotransmitters such as dopamine and serotonin, as well as the oxidation of retinaldehyde in the visual cycle. Mutations in the genes encoding aldehyde dehydrogenase have been linked to various diseases and conditions, including alcohol sensitivity, susceptibility to hangovers, and certain types of cancer. Overall, aldehyde dehydrogenase is crucial for the detoxification and metabolism of aldehydes, and its dysfunction can lead to significant physiological and pathological effects.
9028-86-8
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Basic information
- Product Name: ALDEHYDE DEHYDROGENASE
- Synonyms: EC 1.2.1.5;EC: 1.2.1.5;ALDEHYDE: NAD + (P+) OV REDUCTASE;ALDEHYDE NAD(P)+ OXIDOREDUCTASE;ALDEHYDE: NAD (P) + OXIDOREDUCTASE;ALDEHYDE: NAD(P) OXIDOREDUCTASE;ALDEHYDE DEHYDROGENASE, YEAST;ALDEHYDE DEHYDROGENASE, POTASSIUM-ACTIVATED BAKER'S YEAST (S CEREVISIAE)
- CAS NO:9028-86-8
- Molecular Formula:
- Molecular Weight:
- EINECS: 232-846-3
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: white/lyophilized powder
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: −20°C
- Solubility: N/A
- CAS DataBase Reference: ALDEHYDE DEHYDROGENASE(CAS DataBase Reference)
- NIST Chemistry Reference: ALDEHYDE DEHYDROGENASE(9028-86-8)
- EPA Substance Registry System: ALDEHYDE DEHYDROGENASE(9028-86-8)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: 22-24/25
- WGK Germany: 3
- RTECS:
- F: 3-10
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 9028-86-8(Hazardous Substances Data)
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9028-86-8 Usage
Uses
Used in Pharmaceutical Industry:Aldehyde dehydrogenase is used as a therapeutic target for the treatment of alcohol-related disorders, such as alcoholism and alcohol-induced liver diseases. By modulating the activity of this enzyme, it is possible to reduce the harmful effects of alcohol consumption and improve the management of these conditions.
Used in Research and Development:
Aldehyde dehydrogenase is used as a research tool for studying the metabolism of alcohol and neurotransmitters, as well as the role of this enzyme in various diseases and conditions. Understanding the function and regulation of aldehyde dehydrogenase can help in the development of new drugs and therapies for the treatment of alcohol-related disorders and other diseases associated with aldehyde metabolism.
Used in Diagnostics:
Aldehyde dehydrogenase can be used as a biomarker for the assessment of alcohol sensitivity and the risk of developing alcohol-related disorders. Genetic testing for mutations in the genes encoding aldehyde dehydrogenase can also help in the identification of individuals who are more susceptible to the harmful effects of alcohol consumption.
Used in Drug Metabolism Studies:
Aldehyde dehydrogenase is used in the study of drug metabolism, as it plays a role in the oxidation of various drugs and xenobiotics. Understanding the role of this enzyme in drug metabolism can help in the design of safer and more effective drugs, as well as in the prediction of potential drug-drug interactions and adverse effects.
Check Digit Verification of cas no
The CAS Registry Mumber 9028-86-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,2 and 8 respectively; the second part has 2 digits, 8 and 6 respectively.Calculate Digit Verification of CAS Registry Number 9028-86:
(6*9)+(5*0)+(4*2)+(3*8)+(2*8)+(1*6)=108
108 % 10 = 8
So 9028-86-8 is a valid CAS Registry Number.
9028-86-8Upstream product
9028-86-8Downstream Products
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ALDEHYDE DEHYDROGENASE
