9029-12-3

Basic information

• Product Name: GLDH
• Synonyms: dehydrogenase,glutamate(nicotinamideadeninedinucleotide(phosphate));GLDH;GLUTAMATE DEHYDROGENASE, BOVINE;GLUTAMATE DEHYDROGENASE (BOVINE LIVER);glutamate dehydrogenase F. bovine liver;L-GLUTAMIC DEHYDROGENASE TYPE II*FROM BO VINE LIVER;GLUTAMATE DEHYDROGENASE F. BOVINE LIVER, LYO.,STAB.,>10U/MG;L-GLUTAMIC DEHYDROGENASE TYPE III*FROM B OVINE LIVER
• CAS NO: 9029-12-3
• Molecular Weight: 0
• EINECS: 232-848-4
• Mol File: 9029-12-3.mol
• Article Data: 0

Chemical Properties

• Appearance: amber/solution (viscous)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: GLDH(CAS DataBase Reference)
• NIST Chemistry Reference: GLDH(9029-12-3)
• EPA Substance Registry System: GLDH(9029-12-3)

Safety Data

• WGK Germany: 3
• F: 3-10
• Hazardous Substances Data: 9029-12-3(Hazardous Substances Data)

Usage

Uses

L-Glutamic Dehydrogenase was used to catalyzes the conversion of isocitrate into a-ketoglutarate and carbon dioxide.

Biochem/physiol Actions

Mammalian forms of this enzyme, including this bovine form, can use either NADP(H) or NAD(H) as coenzymes. L-glutamic dehydrogenase plays a unique role in mammalian metabolism. The reverse reaction catalyzed by this enzyme is the only pathway by which ammonia can become bound to the α-carbon atom of an α-carboxylic acid and thus, is the only source of de novo amino acid synthesis in mammalian species. The bovine enzyme is characterized by three sets of properties: It has a reversible concentration-dependent association, producing higher molecular weight forms.Forms tight enzyme-reduced coenzyme-substrate ternary complexes whose rates of dissociation modulate the steady-state reaction rates.Exhibits a wide variety of effects from the binding of any of a number of nucleotide modifiers.L-glutamic dehydrogenase catalyzes the conversion of glutamate to α-ketoglutarate.