EC 2.4.2.4, also known as thymidine phosphorylase, is an enzyme that catalyzes the reversible phosphorolysis of thymidine to thymine and 2-deoxy-D-ribose-1-phosphate. It plays a crucial role in the salvage pathway of pyrimidine nucleotide synthesis and has been implicated in various biological processes, including DNA repair, cell proliferation, and angiogenesis.
Used in Pharmaceutical Industry:
EC 2.4.2.4 is used as a biomarker for evaluating the response of advanced breast cancer patients to capecitabine-based first-line chemotherapy. It helps in assessing the clinical efficacy of nucleoside analogues and provides insights into the treatment outcomes.
Used in Oncology Research:
EC 2.4.2.4 is used as a biomarker to assess the effectiveness of TAS-102 treatment in patients with advanced solid tumors. It aids in understanding the implications of the treatment on patient outcomes and contributes to the development of personalized cancer therapies.
Used in Cancer Biology Studies:
EC 2.4.2.4 is used as a target for investigating the antitumor effects of the FP3 protein on patient-derived tumor tissue xenograft models of primary colon carcinoma. It helps in understanding the molecular mechanisms underlying the antitumor activity of the FP3 protein and its potential as a therapeutic agent.
Used in Pharmaceutical Industry:
EC 2.4.2.4 is used as a biomarker for evaluating the response of advanced breast cancer patients to capecitabine-based first-line chemotherapy. It helps in assessing the clinical efficacy of nucleoside analogues and provides insights into the treatment outcomes.
Used in Oncology Research:
EC 2.4.2.4 is used as a biomarker to assess the effectiveness of TAS-102 treatment in patients with advanced solid tumors. It aids in understanding the implications of the treatment on patient outcomes and contributes to the development of personalized cancer therapies.
Used in Cancer Biology Studies:
EC 2.4.2.4 is used as a target for investigating the antitumor effects of the FP3 protein on patient-derived tumor tissue xenograft models of primary colon carcinoma. It helps in understanding the molecular mechanisms underlying the antitumor activity of the FP3 protein and its potential as a therapeutic agent.
9030-23-3
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Basic information
- Product Name: EC 2.4.2.4
- Synonyms: THYMIDINE PHOSPHORYLASE FROM*ESCHERICHIA COLI;THYMIDINE PHOSPHORYLASE, RECOMBINANT*FRO M E. COLI;THYMIDINE PHOSPHORYLASE, ASEPTICALLY*FIL LED, FROM E;thymidine:orthophosphate deoxy-d-ribosyltransferase;Thymidine Phosphorylase, recombinant from Escherichia coli;MNGIE;ANTI-ECGF1 (CENTER) antibody produced in rabbit;ECGF1
- CAS NO:9030-23-3
- Molecular Formula:
- Molecular Weight: 0
- EINECS: N/A
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /buffered aqueous solution
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: 2-8°C
- Solubility: N/A
- CAS DataBase Reference: EC 2.4.2.4(CAS DataBase Reference)
- NIST Chemistry Reference: EC 2.4.2.4(9030-23-3)
- EPA Substance Registry System: EC 2.4.2.4(9030-23-3)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany: -
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 9030-23-3(Hazardous Substances Data)
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Biochem/physiol Actions
An enzyme that catalyzes the reversible conversion of thymidine to thymine. Thymidine phosphorylase is part of the pyrimidine nucleoside salvage pathway. This pathway allows pyrimidine bases to be recycled for nucleotide biosynthesis, while the pentose 1-phosphates are converted to intermediates of the pentose phosphate shunt and glycolysis. The E. coli thymidine phosphorylase shares 40% sequence homology with the human sequence, which has been found to be identical to the angiogenic agent platelet-derived endothelial growth factor. The purified E. coli enzyme has been shown to stimulate blood vessel growth in chick chorioallantoic membrane assays.Check Digit Verification of cas no
The CAS Registry Mumber 9030-23-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,3 and 0 respectively; the second part has 2 digits, 2 and 3 respectively.Calculate Digit Verification of CAS Registry Number 9030-23:
(6*9)+(5*0)+(4*3)+(3*0)+(2*2)+(1*3)=73
73 % 10 = 3
So 9030-23-3 is a valid CAS Registry Number.
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EC 2.4.2.4
