90301-68-1

Upstream product

• 23956-12-9 5-(2-hydroxyethyl)-uracil 
• 37107-74-7 5,6-dihydrofuro<2,3-d>pyrimidin-2(3H)-one 

Downstream Products

• 90301-69-2 5-(2-chloroethyl)-1-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)-1H,3H-pyrimidine-2,4-dione 
• 90301-63-6 5-(2-chloroethyl)-1-(2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl)-1H,3H-pyrimidine-2,4-dione 
• 90301-59-0 5-(2-chloroethyl)-1-(2-deoxy-β-D-erythro-pentofuranosyl)-1H,3H-pyrimidine-2,4-dione 
• 90301-73-8 5-(2-chloroethyl)-1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-1H,3H-pyrimidine-2,4-dione 
• 108034-57-7 1-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-(2-chloroethyl)-1H,3H-pyrimidine-2,4-dione 

Relevant academic research and scientific papers

Nucleoside analogues

Nucleoside analogues containing the degenerate base analogue P and derivatives thereof are provided with reporter moieties preferably comprising signal moieties. The nucleoside analogues are useful for labeling DNA or RNA or for incorporating in oligonucleotides.

Steric fixation of bromovinyluracil: Synthesis of furo[2,3-d]pyrimidine nucleosides

A new synthetic proccdure for the preparation of 5,6-dihydrofuro[2,3-d]pyrimidin-2(3H)-one (3) and its deoxyriboside 8 is reported. Compound 3 undergoes nucleophilic reactions with various agents to yield 5-substituted uracil derivatives. The dehydro derivative of 3, furo[2,3-d]pyrimidin-2(3H)-one (18) was synthesized by cyclization of BVU 15, which made us develop a reproducible and high yield method for the synthesis of BV(D)U. Starting from 18, the α-deoxyriboside 20 and the β-riboside 22 were prepared.

Preparation of thionucleosides

The invention relates to the preparation of homochiral thiolactones which have application in the synthesis of 3?- and 4?- thionucleosides. Substituents on the thiolactone can be used to influence the configuration of the C-1? position in the final nucleoside. Configuration at the C-4? position is controlled by use of the appropriate homochiral glycidol as starting material in the synthesis of the thiolactone. This process also offers the possibility of introducing substituents diastereoselectively in the C-2? and C-3? positions.

5-(Haloalkyl)-2'-deoxyuridines: A Novel Type of Potent Antiviral Nucleoside Analogue

Syntheses of 5-(2-haloethyl)-2'-deoxyuridines, 5-(3-chloropropyl)-2'-deoxyuridines, and 5-(2-chloroethyl)-2'-deoxycytidine are described.The antiviral activities of these compounds were determined in cell culture against herpes simplex virus types 1 and 2