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9031-02-1

ALPHA-KETOGLUTARATE DEHYDROGENASE, also known as α-ketoglutarate dehydrogenase, is an enzyme complex that plays a crucial role in the citric acid cycle, also known as the Krebs cycle or the tricarboxylic acid (TCA) cycle. It is responsible for catalyzing the decarboxylation of α-ketoglutarate to succinyl-CoA, which is an essential step in the conversion of glucose into energy. The enzyme is typically derived from porcine heart and has various applications in research and analysis.

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  • 9031-02-1 Structure

  • Basic information

    1. Product Name: ALPHA-KETOGLUTARATE DEHYDROGENASE
    2. Synonyms: MULTIENZYME 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, (1) INCLUDING EC 1.2.4.2;ALPHA-KETOGLUTARATE DEHYDROGENASE;A-ketoglutarate dehydrogenase from*porcine heart;multienzyme 2-oxoglutarate dehydrogenase complex;α-ketoglutarate dehydrogenase from porcine heart;α-Ketoglutarate Dehydrogenase
    3. CAS NO:9031-02-1
    4. Molecular Formula:
    5. Molecular Weight: 0
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 9031-02-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /buffered aqueous glycerol solution
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: −20°C
    8. Solubility: N/A
    9. CAS DataBase Reference: ALPHA-KETOGLUTARATE DEHYDROGENASE(CAS DataBase Reference)
    10. NIST Chemistry Reference: ALPHA-KETOGLUTARATE DEHYDROGENASE(9031-02-1)
    11. EPA Substance Registry System: ALPHA-KETOGLUTARATE DEHYDROGENASE(9031-02-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 9031-02-1(Hazardous Substances Data)

9031-02-1 Usage

Uses

Used in Cellular Research:
ALPHA-KETOGLUTARATE DEHYDROGENASE is used as a research tool for studying the reversal of nitration by glutathione (GSH) in peroxynitrite-treated cells. This application helps in understanding the cellular response to oxidative stress and the role of the enzyme in maintaining cellular homeostasis.
Used in Enzyme Activity Measurement:
ALPHA-KETOGLUTARATE DEHYDROGENASE is used as a standard to measure its activity using a Spectramax M5 microplate spectrofluorimeter with heart mitochondria. This method allows researchers to quantify the enzyme's activity and assess its functionality in various experimental conditions.
Used as a Positive Control in Neuronal Studies:
ALPHA-KETOGLUTARATE DEHYDROGENASE is used as a positive control to evaluate its activity in mice neurons using a Spectramax GEMINI EM fluorescence microplate reader. This application is essential for comparing the enzyme's activity in different cell types and understanding its role in neuronal function and metabolism.

Biochem/physiol Actions

α-Ketoglutarate dehydrogenase (α-KGDH) is a key enzyme of bioenergetic processes and a controlling unit of metabolic flux through the Krebs cycle or tricarboxylic acid (TCA) cycle. It catalyzes the oxidative decarboxylation of α-ketoglutarate (KG) to succinyl-CoA by releasing reduced nicotinamide adenine dinucleotide (NADH). It is the rate-limiting reaction of the TCA cycle. This reaction contributes to the electrons of the respiratory chain and requires thiamine pyrophosphate as a cofactor. The reduction of NAD (nicotinamide adenine dinucleotide) is observed to determine its reaction rate. α-KGDH from porcine has an optimum pH range of 6.6–7.4. This enzyme is inhibited by oxidative stress and results in a metabolic deficiency. However, α-KGDH is also known to produce reactive oxygen species (ROS) leading to oxidative stress. Defective or limited levels of α-KGDH cause several neurodegenerative diseases such as Alzheimer′s disease.

Check Digit Verification of cas no

The CAS Registry Mumber 9031-02-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,3 and 1 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 9031-02:
(6*9)+(5*0)+(4*3)+(3*1)+(2*0)+(1*2)=71
71 % 10 = 1
So 9031-02-1 is a valid CAS Registry Number.

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