9031-72-5

Usage

Uses

Used in Biotransformation:
EC 1.1.1.1 is used as a biocatalyst for the synthesis of enantiomerically pure stereoisomers of chiral alcohols. This application is particularly important in the pharmaceutical and chemical industries, where the production of chiral compounds with high purity is essential for the development of effective and safe drugs.
Used in Detoxification:
In humans and many other animals, EC 1.1.1.1 is used as a detoxification enzyme to break down toxic alcohols, such as methanol and ethanol, into less harmful substances. This helps to prevent the accumulation of toxic alcohols in the body and protect against their harmful effects.
Used in Fermentation:
In yeast, plants, and many bacteria, EC 1.1.1.1 is used as a catalyst in fermentation processes to ensure a constant supply of NAD+. This is crucial for the efficient conversion of sugars into energy and the production of various metabolites, which are essential for the growth and survival of these organisms.

Properties

The alcohol dehydrogenases comprise a group of several?isozymes?that catalyse the oxidation of primary and secondary alcohols to aldehydes and ketones, respectively, and also can catalyse the reverse reaction.In mammals this is a?redox?(reduction/oxidation) reaction involving the?coenzyme?nicotinamide adenine dinucleotide?(NAD+).

Synthetic route

alcohol dehydrogenase → denaturated alcohol dehydrogenase

Conditions	Yield
With guanidine hydrochloride

Relevant academic research and scientific papers

Immobilization of proteins with polyurethane polymers

A protein which can be an enzyme is immobilized by: (a) admixing the protein and an isocyanate-capped liquid polyurethane prepolymer in the absence of water to form a resulting mixture (an intermediate product); and (b) forming the intermediate product by reacting it with water to form a polyurethane foam comprising the immobilized enzyme. When certain proteins in sufficient amount are mixed with the prepolymer in the absence of water the resultant protein prepolymer mixture will solidify to produce a solid non-foamed product containing a protein immobilized therein. Initially mixing the protein and prepolymer in the absence of water results in immobilization of a substantially greater amount of protein than when water is present.

Compounds for enzyme amplification assay methadone analogs

Novel biological assay method for determining the presence of a specific organic material by employing a modified enzyme for amplification. By employing receptors specific for one or a group of material (hereinafter referred to as "ligands") and binding an enzyme to the ligand or ligand counterfeit to provide and "enzyme-bound-ligand", an extremely sensitive method is provided for assaying for ligands. The receptor when bound to the enzyme-bound-ligand substantially inhibits enzymatic activity, providing for different catalytic efficiencies of enzyme-bound-ligand and enzyme-bound-ligand combined with receptor. The receptor, ligand and enzyme-bound-ligand are combined in an arbitrary order and the effect of the presence of ligand on enzymatic activity determined. Various protocols may be used for assaying for enzymatic activity and relating the result to the amount of ligand present.