Phosphorylase a, also known as phosphorylase kinase, is an enzyme that plays a crucial role in the regulation of glycogen metabolism. It catalyzes the conversion of glycogen to glucose-1-phosphate, which is then converted to glucose-6-phosphate and enters the glycolytic pathway for energy production. Phosphorylase a is activated by the phosphorylation of phosphorylase b, a process mediated by phosphorylase kinase in the presence of 32P-ATP.
9032-10-4
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Basic information
- Product Name: PHOSPHORYLASE A
- Synonyms: PHOSPHORYLASE A;1,4-ALPHA-D-GLUCAN: ORTHOPHOSPHATE ALPHA-D-GLUCOSYLTRANSFERASE;EC 2.4.1.1;phosphorylase A from rabbit muscle;1,4-α-d-glucan:orthophosphate α-d-glucosyltransferase
- CAS NO:9032-10-4
- Molecular Formula:
- Molecular Weight: 0
- EINECS: 232-878-8
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /lyophilized powder
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: −20°C
- Solubility: N/A
- CAS DataBase Reference: PHOSPHORYLASE A(CAS DataBase Reference)
- NIST Chemistry Reference: PHOSPHORYLASE A(9032-10-4)
- EPA Substance Registry System: PHOSPHORYLASE A(9032-10-4)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany: 3
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 9032-10-4(Hazardous Substances Data)
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9032-10-4 Usage
Uses
Used in Biochemical Research:Phosphorylase a is used as a research tool for studying the molecular mechanisms of glycogen metabolism and the regulation of enzyme activity. It has been employed in studies to assess the effects of various compounds, such as oleanolic acid, on the activity of phosphorylase.
Used in Pharmaceutical Industry:
Phosphorylase a is used as a target enzyme for the development of drugs that modulate glycogen metabolism and energy production in the body. These drugs may have potential applications in the treatment of metabolic disorders, such as diabetes and hypoglycemia, as well as in enhancing athletic performance.
Used in Enzyme Assay Development:
Phosphorylase a is used as a standard enzyme in the development and optimization of enzyme assays for the measurement of glycogen metabolism and enzyme activity. These assays are essential for understanding the biochemical pathways and regulatory mechanisms involved in glycogen metabolism.
Used in Education and Training:
Phosphorylase a serves as an educational tool for teaching students and researchers about the biochemical processes of glycogen metabolism and the role of enzymes in regulating metabolic pathways. It is used in laboratory experiments and demonstrations to illustrate the principles of enzyme kinetics, regulation, and the conversion of phosphorylase b to a.
Biochem/physiol Actions
Phosphorylase A can be inhibited by these compounds: Polychlorinated biphenyls, polychlorinated biphenylols and polybrominated biphenyls.Check Digit Verification of cas no
The CAS Registry Mumber 9032-10-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,3 and 2 respectively; the second part has 2 digits, 1 and 0 respectively.Calculate Digit Verification of CAS Registry Number 9032-10:
(6*9)+(5*0)+(4*3)+(3*2)+(2*1)+(1*0)=74
74 % 10 = 4
So 9032-10-4 is a valid CAS Registry Number.
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PHOSPHORYLASE A
