90323-61-8Relevant articles and documents
REACTIONS OF TITANIUM DERIVATIVES OF CERTAIN CH ACIDS WITH CARBONYL COMPOUNDS. I. CROTONIC CONDENSATIONS WITH THE TITANIUM DERIVATIVES OF MALONIC ESTER, CYANOACETIC ESTER, AND MALONONITRILE
Kasatkin, A. N.,Biktimirov, R. Kh.,Tolstikov, G. A.,Khalilov, L. M.
, p. 1029 - 1037 (2007/10/02)
The titanium derivatives of malonic ester, cyanoacetic ester, and malononitrile obtained by the reaction of the corresponding sodium salts with (i-PrO)3TiCl, react with aldehydes in THF at -78 to 20 deg C, forming the products from crotonic condensation.If α,β-unsaturated aliphatic α-bromo and keto aldehydes are used, the yields of the corresponding alkylidenemalonic and alkylidenecyanoacetic esters are substantially higher than under the conditions of the Knoevenagel reaction.