903344-56-9Relevant academic research and scientific papers
Synthesis and biological evaluation of novel curcumin analogues as anti-inflammatory, anti-cancer and anti-oxidant agents
Bandgar, Babasaheb P.,Hote, Baliram S.,Jalde, Shivkumar S.,Gacche, Rajesh N.
, p. 3006 - 3014 (2012)
A series of novel curcumin analogues 5a- m were synthesized by Claisen-Schmidt condensation of various aromatic and heteroaromatic amides of 3-aminoactophenones 4a-m with 3-bromo-2,4,6-trimethoxybenzaldehyde and characterized by IR, 1H NMR and mass spectroscopic analysis and were evaluated for anti-inflammatory, anti-cancer and anti-oxidant activity. Out of the 13 synthesized compounds, compounds 5f, 5j and 5m were excellent inhibitors of TNF-α and IL-6. Compounds 5c, 5e, 5b and 5d showed potent COX-2 inhibition, compounds 5d and 5f have shown good trypsin inhibition and compounds 5e, 5g and 5c exhibited excellent β-glucuronidase inhibition. Compounds 5l and 5m showed potent anti-cancer activity against selected five human cancer cell lines. All the compounds exhibited moderate free radical scavenging activity, while compounds 5a and 5m were excellent OH radical scavengers. Springer Science+Business Media, LLC 2011.
Synthesis and antioxidant, cytotoxicity and antimicrobial activities of novel curcumin mimics
Bandgar, Babasaheb P.,Jalde, Shivkumar S.,Korbad, Balaji L.,Patil, Sachin A.,Chavan, Hemant V.,Kinkar, Santosh N.,Adsul, Laxman K.,Shringare, Sadanand N.,Nile, Shivraj H.
scheme or table, p. 267 - 274 (2012/07/13)
Claisen-Schmidt condensation of 3-(1,2,3,6-tetrahydro-1-methylpyridin-4-yl) -2,4,5-trimethoxybenzaldehyde 3 and various aromatic, heterocyclic and alicyclic amides of 3-aminoacetophenone 6(as) afforded novel curcumin mimics. All the synthesized compounds
