90344-84-6 Usage
Uses
Used in Anticancer Applications:
5-Fluorouracil-6-d1 is used as a potent antineoplastic agent in clinical use, particularly for the treatment of various types of cancer. It functions as an inhibitor of DNA synthesis, which leads to the disruption of cell replication and ultimately the death of cancer cells. Its deuterated nature provides enhanced stability and selectivity, making it a valuable tool in cancer research and therapy.
Used in Cancer Research:
5-Fluorouracil-6-d1 is used as a research tool in cancer biology, allowing scientists to study the mechanisms of action and resistance to 5-FU in cancer cells. Its deuterated form offers unique advantages in experimental settings, such as reduced metabolism and improved detection using mass spectrometry techniques. This enables researchers to gain a deeper understanding of the molecular pathways involved in cancer development and progression, ultimately leading to the development of more effective therapeutic strategies.
Used in Drug Development:
5-Fluorouracil-6-d1 is employed in the development of new anticancer drugs, as its deuterated nature can potentially improve the pharmacokinetic and pharmacodynamic properties of 5-FU. By studying the effects of 5-Fluorouracil-6-d1 on cancer cells, researchers can identify novel targets and design more effective drugs with reduced side effects and increased efficacy.
Used in Drug Metabolism Studies:
5-Fluorouracil-6-d1 is used in drug metabolism studies to investigate the metabolic pathways and enzymes involved in the biotransformation of 5-FU. Understanding these processes can help in the optimization of drug dosages and schedules, as well as the development of strategies to overcome drug resistance in cancer treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 90344-84-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,0,3,4 and 4 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 90344-84:
(7*9)+(6*0)+(5*3)+(4*4)+(3*4)+(2*8)+(1*4)=126
126 % 10 = 6
So 90344-84-6 is a valid CAS Registry Number.
InChI:InChI=1/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)/i1D
90344-84-6Relevant academic research and scientific papers
An Unusual Substituent Effect on Elimination vs Fragmentation Reactions of the Dianions of 5-Fluorouracil-Alkene Photoadducts. Preparation of Cyclobutane-Annelated Uracils
Swenton, John S.,Jurcak, John G.
, p. 1530 - 1534 (2007/10/02)
Acetone-sensitized photocycloadditions of 5-fluorouracil to methyl vinyl ether, 2-methoxypropene, and ketene dimethyl acetal give good yields of the respective 8,8-disubstituted-6-fluoro-2,4-diazabicyclooctane-3,5-diones.Whereas the dianions of cycloadducts of 5-fluorouracil and alkyl-substituted alkenes afford high yields of 5-substituted uracils, the products from 2-methoxypropene and ketene dimethyl acetal give predominantly cyclobutane-annelated uracils derived from syn elimination of hydrogen fluoride.Deuterium labeling studies support the proposed mechanism of elimination.Heating 8,8-dimethoxy-2,4-diazabicyclooct-1(6)-ene-3,5-dione, obtained from hydrogen fluoride elimination of the 5-fluorouracil-ketene dimethyl acetal photoadduct, in the presence of N-phenylmaleimide or dimethyl acetylenedicarboxylate, gives Diels-Alder adducts derived from trapping the thermally generated diene.
A Novel Mechanism for Conversion of 5-Fluorouracil-Olefin Photocycloaddition Products to 5-Substituted Uracils. A Synthon for the Uracil 5-Carbanion
Wexler, Allan J.,Balchunis, Robert J.,Swenton, John S.,Kaminski, Victor V.
, p. 2738 - 2743 (2007/10/02)
The photocycloaddition products of 5-fluorouracil and enol acetates undergo fragmentation reactions to afford 5-substituted uracils in good yields.Unexpectedly, certain 5-fluorouracil-olefin photocycloaddition products react with 3 equiv of potassium tert
