90347-86-7

Usage

Uses

Used in Pharmaceutical Industry:
Benzamide, 4-ethynyl(9CI) serves as a crucial precursor in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with specific therapeutic properties, contributing to advancements in medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, Benzamide, 4-ethynyl(9CI) is utilized as a starting material for the preparation of agrochemicals. Its reactivity and properties enable the creation of effective compounds for agricultural applications, such as pesticides and herbicides.
Used in Organic Synthesis:
Benzamide, 4-ethynyl(9CI) is employed as a versatile building block in the development of novel materials. Its unique reactivity allows for the synthesis of complex organic molecules, which can be used in a wide range of applications, from specialty chemicals to advanced materials.
Used in Research and Development:
Benzamide, 4-ethynyl(9CI)'s potential as a starting material in the synthesis of complex organic molecules makes it an invaluable tool for research and development in the field of organic chemistry. It facilitates the exploration of new chemical reactions and the discovery of innovative applications for organic compounds.

Upstream product

• 586-89-0 4-acetyl-benzoic acid 
• 3032-92-6 4-cyanophenylacetylene 
• 10602-00-3 4-Ethynyl-benzoic acid 
• 698-67-9 p-bromobenzamide 
• 863640-43-1 4-(trimethylsilanylethynyl)benzamide 

Downstream Products

• 851227-28-6 {4-[3-(4-carbamoylphenylethynyl)-5-isopropyl-4-methoxymethoxybenzyl]-3,5-dimethylphenoxy}acetic acid methyl ester 
• 1108612-40-3 5-(4-Carbamoyl-phenylethynyl)-N-[2-cyano-1-(1H-indol-3-ylmethyl)-ethyl]-2-isopropoxy-benzamide 
• 1357457-35-2 C₁₉H₂₀ClN₅O₄ 
• 1260025-39-5 C₂₄H₁₅ClFN₃O 
• 97923-13-2 1-Diphenylhydroxymethyl-4-(3',3'-diphenylhydroxy-1'-propinyl)-benzol 
• 105791-35-3 1-Diphenylchlormethyl-4-(3'-chlor-3',3'-diphenyl-1'-propinyl)-benzol 

Relevant academic research and scientific papers

Visible light-mediated synthesis of amides from carboxylic acids and amine-boranes

Here, a photocatalytic deoxygenative amidation protocol using readily available amine-boranes and carboxylic acids is described. This approach features mild conditions, moderate-to-good yields, easy scale-up, and up to 62 examples of functionalized amides with diverse substituents. The synthetic robustness of this method was also demonstrated by its application in the late-stage functionalization of several pharmaceutical molecules.

PROCESS FOR HYDROCYANATION OF TERMINAL ALKYNES

The present invention refers to a process for a Rh-catalyzed Anti-Markovnikov hydrocyanation of terminal alkynes which process discloses, for the first time, the highly stereo- and regio-selective hydrocyanation of terminal alkynes to furnish E- configured alkenyl nitriles and the catalyst used in the present process.

Rh-Catalyzed Anti-Markovnikov Hydrocyanation of Terminal Alkynes

We report the first highly stereo- and regioselective hydrocyanation of terminal alkynes to furnish E-configured alkenyl nitriles. Acrylonitriles can be accessed on gram scale with broad substrate scope and functional group tolerance. The hydrocyanation reaction employs acetone cyanohydrin as a practical alternative to HCN gas.

ALKYNYL PHOSPHINE GOLD COMPLEXES FOR TREATING BACTERIAL INFECTIONS

A compound of formula (I) for use in the prevention or treatment of a bacterial infection.

NOVEL CONDENSED PYRAZOLE DERIVATIVE AND MEDICAL USES THEREOF

PROBLEM TO BE SOLVED: To provide a preventive or therapeutic agent for mood disorder, anxiety disorder, schizophrenia, dementia, drug dependence or the like related to subtypes of metabolism type glutamate receptor (mGlu) 2 and 3. SOLUTION: There are prov

Transition-metal-free hydration of nitriles using potassium tert -butoxide under anhydrous conditions

Potassium tert-butoxide acts as a nucleophilic oxygen source during the hydration of nitriles to give the corresponding amides under anhydrous conditions. The reaction proceeds smoothly for a broad range of substrates under mild conditions, providing an efficient and economically affordable synthetic route to the amides in excellent yields. This protocol does not need any transition-metal catalyst or any special experimental setup and is easily scalable to bulk scale synthesis. A single-electron-transfer radical mechanism as well as an ionic mechanism have been proposed for the hydration process.

Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1-Nrf2 Protein-Protein Interaction

The transcription factor Nrf2 regulates the expression of a large network of cytoprotective and metabolic enzymes and proteins. Compounds that directly and reversibly inhibit the interaction between Nrf2 and its main negative regulator Keap1 are potential pharmacological agents for a range of disease types including neurodegenerative conditions and cancer. We describe the development of a series of 1,4-diphenyl-1,2,3-triazole compounds that inhibit the Nrf2-Keap1 protein-protein interaction (PPI) in vitro and in live cells and up-regulate the expression of Nrf2-dependent gene products.

A general and efficient heterogeneous gold-catalyzed hydration of nitriles in neat water under mild atmospheric conditions

Mild, efficient and general: Titania decorated with nanometer-sized gold particles acts as an efficient catalyst for the selective hydration of a wide range of chemically diverse nitriles into valuable amides in neutral water, under mild atmospheric conditions (see image). The process shows promise for a facile and direct one-pot synthesis of ?μ-caprolactam, an industrially important molecule, starting from 6-aminocapronitrile. Copyright

Hammett analysis of selective thyroid hormone receptor modulators reveals structural and electronic requirements for hormone antagonists

Selective thyroid hormone modulators that function as isoform-selective agonists or antagonists of the thyroid hormone receptors (TRs) might be therapeutically useful in diseases associated with aberrant hormone signaling. The most potent thyroid hormone