90349-14-7 Usage
Uses
Used in Chemical Synthesis:
2,5-DIMETHYL-4-NITROBENZIMIDAZOLE is used as an intermediate in the chemical synthesis industry for the production of dyes, pigments, and pharmaceuticals. Its unique structure, featuring a nitro group, facilitates its reactivity and makes it a key component in the creation of a variety of organic compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 2,5-DIMETHYL-4-NITROBENZIMIDAZOLE is utilized as a precursor in the synthesis of various medicinal compounds. Its chemical properties allow it to be a building block for the development of new drugs, contributing to the advancement of pharmaceutical formulations.
Used in Dye and Pigment Production:
2,5-DIMETHYL-4-NITROBENZIMIDAZOLE is employed as a key intermediate in the dye and pigment industry. Its ability to contribute to the color and stability of dyes and pigments makes it an essential component in the manufacturing process of these products.
Safety Considerations:
Given the potential mutagenic effects of 2,5-DIMETHYL-4-NITROBENZIMIDAZOLE, it is crucial to handle this chemical with care in laboratory settings. Proper safety protocols and adherence to regulations are mandatory to minimize any health hazards associated with its use.
Check Digit Verification of cas no
The CAS Registry Mumber 90349-14-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,0,3,4 and 9 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 90349-14:
(7*9)+(6*0)+(5*3)+(4*4)+(3*9)+(2*1)+(1*4)=127
127 % 10 = 7
So 90349-14-7 is a valid CAS Registry Number.
InChI:InChI=1/C9H9N3O2/c1-5-3-4-7-8(9(5)12(13)14)11-6(2)10-7/h3-4H,1-2H3,(H,10,11)
90349-14-7Relevant academic research and scientific papers
A novel series of highly potent benzimidazole-based microsomal triglyceride transfer protein inhibitors
Robl,Sulsky,Sun,Simpkins,Wang,Dickson Jr.,Chen,Magnin,Taunk,Slusarchyk,Biller,Lan,Connolly,Kunselman,Sabrah,Jamil,Gordon,Harrity,Wetterau
, p. 851 - 856 (2007/10/03)
A series of benzimidazole-based analogues of the potent MTP inhibitor BMS-201038 were discovered. Incorporation of an unsubstituted benzimidazole moiety in place of a piperidine group afforded potent inhibitors of MTP in vitro which were weakly active in vivo. Appropriate substitution on the benzimidazole ring, especially with small alkyl groups, led to dramatic increases in potency, both in a cellular assay of apoB secretion and especially in animal models of cholesterol lowering. The most potent in this series, 3g (BMS-212122), was significantly more potent than BMS-201038 in reducing plasma lipids (cholesterol, VLDL/LDL, TG) in both hamsters and cynomolgus monkeys.
A useful methodology for the synthesis of 2-methyl-4-nitrobenzimidazoles
Tian,Grivas
, p. 1283 - 1286 (2007/10/02)
Cyclocondensation of 3-nitro-1,2-benzenediamines 2 with 2,4-pentanedione provides a convenient route for the preparation of 2-methyl-4-nitrobenzimidazoles 3. A discrepancy in the literature regarding the 5-chloro-, 5-methoxy- and 5-methyl derivatives of the title compounds is discussed.
