Hemoglobin Manitoba is a rare variant of the hemoglobin molecule, specifically a hemoglobinopathy, caused by a mutation in the beta-globin gene. This genetic alteration results in the substitution of the amino acid glutamic acid with valine at the sixth position of the beta chain. The presence of hemoglobin Manitoba can lead to a mild form of hemolytic anemia, as it affects the molecule's stability and oxygen-carrying capacity. While it is generally asymptomatic and does not require treatment, it is important for medical professionals to be aware of this variant to avoid misdiagnosing it as a more severe hemoglobinopathy, such as sickle cell anemia. Hemoglobin Manitoba is inherited in an autosomal dominant pattern, meaning that an individual only needs to inherit one copy of the mutated gene to express the trait.
The CAS Registry Mumber 9035-09-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,3 and 5 respectively; the second part has 2 digits, 0 and 9 respectively. Calculate Digit Verification of CAS Registry Number 9035-09: (6*9)+(5*0)+(4*3)+(3*5)+(2*0)+(1*9)=90 90 % 10 = 0 So 9035-09-0 is a valid CAS Registry Number.