Blood-coagulation factor XI, also known as FXI, is a plasma glycoprotein that plays a crucial role in the coagulation cascade, which is the process of blood clotting. It is a part of the intrinsic pathway of coagulation and is activated by factor XIIa, which is generated when blood comes into contact with a negatively charged surface. Once activated, FXIa (activated factor XI) can then activate factor IX, which in turn activates factor X, leading to the formation of thrombin and ultimately a stable blood clot. FXI is synthesized in the liver and circulates in plasma at relatively low concentrations. Deficiency in factor XI can lead to a bleeding disorder, while excessive levels or activity can contribute to thrombotic events. Understanding the role of FXI in the coagulation process is important for the development of targeted therapies for both bleeding and clotting disorders.
The CAS Registry Mumber 9035-65-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,3 and 5 respectively; the second part has 2 digits, 6 and 5 respectively. Calculate Digit Verification of CAS Registry Number 9035-65: (6*9)+(5*0)+(4*3)+(3*5)+(2*6)+(1*5)=98 98 % 10 = 8 So 9035-65-8 is a valid CAS Registry Number.
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