903518-01-4Relevant academic research and scientific papers
Synthesis of conformationally constrained lysine analogues
Ganorkar, Rakesh,Natarajan, Amarnath,Mamai, Ahmed,Madalengoitia, Jose S.
, p. 5004 - 5007 (2007/10/03)
The synthesis of two conformationally constrained lysine analogues is reported. The synthesis of the novel analogue 1 based on the 3-aza-bicyclo[3.1.0]hexane system is accomplished from the known tricycle 3 in eight steps. The synthesis of the analogue 2 is accomplished in eight steps from 4-hydroxy proline. Both analogues are synthesized appropriately protected for Fmoc/Boc solid-phase peptide synthesis.
