903561-75-1Relevant academic research and scientific papers
Array synthesis of progesterone receptor antagonists: 3-Aryl-1,2-diazepines
Wiethe, Robert W.,Stewart, Eugene L.,Drewry, David H.,Gray, David W.,Mehbob, Abdul,Hoekstra, William J.
, p. 3777 - 3779 (2006)
New non-steroidal chemotypes are required for the development of drugs targeting the steroid hormone receptors. The parallel array synthesis of 3-aryl-1,2-diazepines employing solid-supported reagents is described. The resulting compounds demonstrated high affinity binding to the progesterone receptor.
