903588-35-2Relevant academic research and scientific papers
Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease
Rosini, Michela,Simoni, Elena,Bartolini, Manuela,Tarozzi, Andrea,Matera, Riccardo,Milelli, Andrea,Hrelia, Patrizia,Andrisano, Vincenza,Bolognesi, Maria Laura,Melchiorre, Carlo
, p. 5435 - 5442 (2011/12/14)
Lipoic acid (LA) is a natural antioxidant. Its structure was previously combined with that of the acetylcholinesterase inhibitor tacrine to give lipocrine (1), a lead compound multitargeted against Alzheimer's disease (AD). Herein, we further explore LA as a privileged structure for developing multimodal compounds to investigate AD. First, we studied the effect of LA chirality by evaluating the cholinesterase profile of 1's enantiomers. Then, a new series of LA hybrids was designed and synthesized by combining racemic LA with motifs of other known anticholinesterase agents (rivastigmine and memoquin). This afforded 4, which represents a step forward in the search for balanced anticholinesterase and antioxidant capacities.
Organic Compounds Useful For The Treatment Of Alzheimer's Disease, Their Use And Method Of Preparation
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Page/Page column 9, (2008/06/13)
Compounds identified by the general formula (I) are used for the treatment of Alzheimer's disease.
