90379-98-9Relevant academic research and scientific papers
A Palladium-Catalyzed Oxa-(4+4)-Cycloaddition Strategy towards Oxazocine Scaffolds
Scuiller, Ana?s,Liu, Xueyang,Cordier, Marie,Garrec, Julian,Archambeau, Alexis
supporting information, p. 981 - 986 (2021/06/02)
A Pd-catalyzed oxa-(4+4)-cycloaddition between 1-azadienes and (2-hydroxymethyl)allyl carbonates is described. Aurone-derived azadienes furnished polycyclic 1,5-oxazocines in good yields. Interestingly, linear azadienes have also been involved and yielded monocyclic heterocycles with complete regioselectivity. DFT calculations were carried out to gain insight on this observation.
An unusual triazole synthesis from aurones
Kafle, Arjun,Bhattarai, Shrijiana,Handy, Scott T.
supporting information, p. 2337 - 2346 (2020/08/19)
Attempts to prepare azido-substituted aurones via a copper-catalyzed azidation failed to afford the desired product, but instead resulted in an unusual triazole formation reaction. Further efforts noted that copper was not required for this reaction, but simply thermal treatment with sodium azide in a polar aprotic solvent. A wide range of substitution patterns were tolerated in this reaction to afford the interesting salicyl-substituted triazoles in modest to excellent yield. While the mechanism is not yet clear, a simple elimination/cyclization pathway seems unlikely given the failure of the reaction on the corresponding thioaurones, which feature an even better thiol leaving group. Regardless, the potential utility of these easily accessible, multifunctional compounds should engender further interest and applications.
THERAPEUTIC AURONES
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Page/Page column 72; 77, (2017/11/10)
Substituted aurones were found to have antitrypanosomal, antifungal and immunomodulatory activity. The invention provides novel aurone compounds, pharmaceutical compositions, and methods encompassing medical and veterinary applications.
Aurone derivatives
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, (2008/06/13)
Substituted aurones of formula (I): STR1 wherein R1, R2, R3, R4, R5 and R6 are the same or different and can each represent hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy, C3-8 cycloalkyl, optionally substituted phenyl, C1-6 haloalkyl, amido, amino, cyano, hydroxy, nitro, C2-4 alkenyl, carboxyl, tetrazol-5-yl and --CH=CHCOOH; or wherein R1 and R2 taken together can represent a group of formula --CH=CH--CH=CH-- provided that at least one of R1, R2, R3, R4, R5 and R6 is carboxyl, tetrazol-5-yl or --CH=CHCOOH; or a pharmaceutically-acceptable salt or ester thereof, are effective in the prophylactic chemotherapy of allergic conditions such as bronchial asthma.
