90384-22-8Relevant academic research and scientific papers
Synthesis, structural characterization, antimicrobial and cytotoxic effects of aziridine, 2-aminoethylaziridine and azirine complexes of copper(ii) and palladium(ii)
Budzisz,Bobka,Hauss,Roedel,Wirth,Lorenz,Rozalska,Wieckowska-Szakiel,Krajewska,Rozalski
, p. 5925 - 5933 (2012)
The synthesis, spectroscopic and X-ray structural characterization of copper(ii) and palladium(ii) complexes with aziridine ligands as 2-dimethylaziridine HNCH2CMe2 (a), the bidentate N-(2-aminoethyl)aziridines C2H4NC2H 4NH2 (b) or CH2CMe2NCH 2CMe2NH2 (c) as well as the unsaturated azirine NCH2CPh (d) are reported. Cleavage of the cyclometallated Pd(ii) dimer [μ-Cl(C6H4CHMeNMe2-C,N)Pd]2 with ligand a yielded compound [Cl(NHCH2CMe2)(C 6H4CHMe2NMe2-C,N)Pd] (1a). The reaction of the aziridine complex trans-[Cl2Pd(HNC2H 4)2] with an excess of aziridine in the presence of AgOTf gave the ionic chelate complex trans-[(C2H4NC 2H4NH2-N,N′)2Pd](OTf) 2 (2b) which contains the new ligand b formed by an unexpected insertion and ring opening reaction of two aziridines ("aziridine dimerization"). CuCl2 reacted in pure HNC2H 4 or HNCH2CMe2 (b) again by "dimerization" to give the tris-chelated ionic complex [Cu(C 2H4NC2H4NH2-N,N′) 3]Cl2 (3b) or the bis-chelated complex [CuCl(C 2H2Me2NC2H2Me 2NH2-N,N′)2]Cl (4c). By addition of 2H-3-phenylazirine (d) to PdCl2, trans-[Cl2Pd(NCH 2CPh)2] (5d) was formed. All new compounds were characterized by NMR, IR and mass spectra and also by X-ray structure analyses (except 3b). Additionally the cytotoxic effects of these complexes were examined on HL-60 and NALM-6 human leukemia cells and melanoma WM-115 cells. The antimicrobial activity was also determined. The growth of Gram-positive bacterial strains (S. aureus, S. epidermidis, E. faecalis) was inhibited by almost all tested complexes at the concentrations of 37.5-300.0 μg mL -1. However, MIC values of complexes obtained for Gram-negative E. coli and P. aeruginosa, as well as for C. albicans yeast, mostly exceeded 300 μg mL-1. The highest antibacterial activity was achieved by complexes 1a and 2b. Complex 2b also inhibited the growth of Gram-negative bacteria.
PREPARATION OF SOME trans-BIS (2H-AZIRINE)PALLADIUM DICHLORIDE COMPLEXES AND THE OPENING OF THEIR AZIRINE RINGS IN BENZENE
Filho, Pedro Faria Dos Santos,Schuchardt, Ulf
, p. 385 - 394 (2007/10/02)
The trans-bis(2H-azirine)palladium dichloride complexes 2f, 2g, 2h and 2i are formed in the reaction of (C6H5CN)2PdCl2 with 3-phenyl- (1f), 2-phenyl-3-styryl-(1g), 2(formyl-N-phenylimine)-3-phenyl- (1h) and 2-styryl-3-phenyl-2H-azirine (1i).The cleavage o
