903899-08-1Relevant academic research and scientific papers
Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists
Wu, Wen-Lian,Burnett, Duane A.,Caplen, Mary Ann,Domalski, Martin S.,Bennett, Chad,Greenlee, William J.,Hawes, Brian E.,O'Neill, Kim,Weig, Blair,Weston, Daniel,Spar, Brian,Kowalski, Timothy
, p. 3674 - 3678 (2007/10/03)
Biaryl urea lead compound 1 was discovered earlier in our MCH antagonist program. Novel benzimidazole analogues with increased chemical stability, devoid of the potential carcinogenic liability associated with a biarylamine moiety, were synthesized and evaluated to be potent MCH R1 antagonists. Two compounds in this series have demonstrated in vivo efficacy in a rodent obesity model.
