EC 1.6.2.4, also known as human cytochrome P450 reductase, is a protein that plays a crucial role in the electron transfer process during the catalytic activity of cytochrome P450 enzymes. It is involved in the reduction of various substrates, including drugs and other xenobiotics, and is essential for the proper functioning of the cytochrome P450 system.
9039-06-9
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Basic information
- Product Name: EC 1.6.2.4
- Synonyms: EC 1.6.2.4;CYTOCHROME P450 REDUCTASE;CYTOCHROME P450 REDUCTASE HUMAN;napdh-cytochromep-450reductase;NADPH: FERRIHEMOPROTEIN OXIDOREDUCTASE;cytochrome P450 reductase from rabbit*liver induc;CYTOCHROME P450 REDUCTASE FROM RABBITLIV ER INDUCED;cytochrome p450 reductase from rabbit liver induced with phenobarbital
- CAS NO:9039-06-9
- Molecular Formula:
- Molecular Weight: 0
- EINECS: N/A
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /buffered aqueous glycerol solution
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: −20°C
- Solubility: N/A
- CAS DataBase Reference: EC 1.6.2.4(CAS DataBase Reference)
- NIST Chemistry Reference: EC 1.6.2.4(9039-06-9)
- EPA Substance Registry System: EC 1.6.2.4(9039-06-9)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany: 3
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 9039-06-9(Hazardous Substances Data)
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9039-06-9 Usage
Uses
Used in Pharmaceutical Industry:EC 1.6.2.4 is used as a biocatalyst for the synthesis and structure elucidation of cyclized metabolites of deacetylase inhibitors, such as panobinostat (LBH589). This helps in understanding the metabolic pathways and potential drug-drug interactions, ultimately contributing to the development of safer and more effective medications.
Used in Biochemistry Research:
EC 1.6.2.4 is used in studies investigating the effects of coupled motions on electrons along the human microsomal P450 chains. This research helps in understanding the molecular mechanisms underlying the function of cytochrome P450 enzymes and their role in drug metabolism and detoxification processes.
Biochem/physiol Actions
The enzyme catalyses electron transfer to cytochrome P450. This system plays a major role in detoxification of drugs and xenobiotics, activation of carcinogens, and metabolism of endogenous substrates such as steroids.Check Digit Verification of cas no
The CAS Registry Mumber 9039-06-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,3 and 9 respectively; the second part has 2 digits, 0 and 6 respectively.Calculate Digit Verification of CAS Registry Number 9039-06:
(6*9)+(5*0)+(4*3)+(3*9)+(2*0)+(1*6)=99
99 % 10 = 9
So 9039-06-9 is a valid CAS Registry Number.
9039-06-9Upstream product
9039-06-9Downstream Products
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EC 1.6.2.4
