90396-06-8 Usage
General Description
6-Chloro-1,2,3,4-tetrahydro-1lambda6-benzothiine-1,1,4-trione, also known as tiglutik, is a chemical compound used in the treatment of amyotrophic lateral sclerosis (ALS). It works by reducing the levels of glutamate in the brain, which is believed to play a role in the progression of ALS. Tiglutik is administered as an oral suspension, making it easier for patients to take the medication. It is important to carefully measure the dose using the provided syringe to ensure the proper amount is taken. Tiglutik has been shown to slow the progression of ALS and improve muscle strength and function in some patients. However, it may also cause side effects such as dizziness, fatigue, and allergic reactions.
Check Digit Verification of cas no
The CAS Registry Mumber 90396-06-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,0,3,9 and 6 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 90396-06:
(7*9)+(6*0)+(5*3)+(4*9)+(3*6)+(2*0)+(1*6)=138
138 % 10 = 8
So 90396-06-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H7ClO3S/c10-6-1-2-9-7(5-6)8(11)3-4-14(9,12)13/h1-2,5H,3-4H2
90396-06-8Relevant articles and documents
Synthesis and biochemical evaluation of thiochromanone thiosemicarbazone analogues as inhibitors of cathepsin L
Song, Jiangli,Jones, Lindsay M.,Kumar, G. D. Kishore,Conner, Elizabeth S.,Bayeh, Liela,Chavarria, Gustavo E.,Charlton-Sevcik, Amanda K.,Chen, Shen-En,Chaplin, David J.,Trawick, Mary Lynn,Pinney, Kevin G.
supporting information; experimental part, p. 450 - 453 (2012/09/25)
A series of 36 thiosemicarbazone analogues containing the thiochromanone molecular scaffold functionalized primarily at the C-6 position were prepared by chemical synthesis and evaluated as inhibitors of cathepsins L and B. The most promising inhibitors f
