90396-06-8

Basic information

• Product Name: 6-CHLORO-1,2,3,4-TETRAHYDRO-1LAMBDA6-BENZOTHIINE-1,1,4-TRIONE
• Synonyms: 6-CHLORO-1,2,3,4-TETRAHYDRO-1LAMBDA6-BENZOTHIINE-1,1,4-TRIONE;6-CHLORO-2,3-DIHYDRO-4H-THIOCHROMEN-4-ONE 1,1-DIOXIDE;6-chloro-1-benzothiopyran-4-one 1,1-dioxide;6-CHLOROTHIOCHROMAN-4-ONE-1,1-DIOXIDE
• CAS NO: 90396-06-8
• Molecular Formula: C₉H₇ClO₃S
• Molecular Weight: 230.67
• Mol File: 90396-06-8.mol

Chemical Properties

• Melting Point: 148-150
• Boiling Point: 467.6°Cat760mmHg
• Flash Point: 236.6°C
• Appearance: /
• Density: 1.524g/cm³
• Vapor Pressure: 6.4E-09mmHg at 25°C
• Refractive Index: 1.608
• CAS DataBase Reference: 6-CHLORO-1,2,3,4-TETRAHYDRO-1LAMBDA6-BENZOTHIINE-1,1,4-TRIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-1,2,3,4-TETRAHYDRO-1LAMBDA6-BENZOTHIINE-1,1,4-TRIONE(90396-06-8)
• EPA Substance Registry System: 6-CHLORO-1,2,3,4-TETRAHYDRO-1LAMBDA6-BENZOTHIINE-1,1,4-TRIONE(90396-06-8)

Safety Data

• Hazard Codes: Xi
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g
• Hazardous Substances Data: 90396-06-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-CHLORO-1,2,3,4-TETRAHYDRO-1LAMBDA6-BENZOTHIINE-1,1,4-TRIONE is used as a therapeutic agent for the treatment of amyotrophic lateral sclerosis (ALS) due to its capacity to reduce glutamate levels in the brain, which is thought to contribute to the disease's progression.
Used in Neurological Treatments:
6-CHLORO-1,2,3,4-TETRAHYDRO-1LAMBDA6-BENZOTHIINE-1,1,4-TRIONE is used as a neuroprotective medication to slow the progression of ALS and improve muscle strength and function in affected patients, offering a potential therapeutic intervention for this currently incurable condition.

InChI:InChI=1/C9H7ClO3S/c10-6-1-2-9-7(5-6)8(11)3-4-14(9,12)13/h1-2,5H,3-4H2

Upstream product

• 67141-35-9 3-<4-Chlor-phenylmercapto>-propionsaeure-chlorid 
• 932047-87-5 3-(4-chlorophenylsulfonyl)propanoyl chloride 
• 13735-12-1 6-chlorothiochroman-4-one 

Downstream Products

• 1021169-07-2 6-{4-[2-((R)-2-methylpyrrolidin-1-yl)ethyl]phenyl}-1,1-dioxo-λ⁶-thiochroman-4-one 

Relevant articles and documents

Synthesis and biochemical evaluation of thiochromanone thiosemicarbazone analogues as inhibitors of cathepsin L

A series of 36 thiosemicarbazone analogues containing the thiochromanone molecular scaffold functionalized primarily at the C-6 position were prepared by chemical synthesis and evaluated as inhibitors of cathepsins L and B. The most promising inhibitors f

MODERN FRIEDEL-CRAFTS CHEMISTRY. XI. CYCLIZATION OF ARYL HALOALKYL SULFONES, ARYLSULFONYLACYL CHLORIDES AND THEIR CORRESPONDING SULFIDES

The sulfone group deactivation for cyclialkylation and cycliacylation reactions in the presence of Friedel-Crafts catalysts was demonstrated in a number of aryl chloroalkylsulfones (1-8) and arylsulfonylacyl chlorides (17a-22a), respectively.As expected, the corresponding arylchloroalkyl sulfides (9-16) and arylmercaptoacyl chlorides (13a-28a) underwent ring-closure reaction in most cases under the same conditions.The ease of cyclization was governed by the ring size, the stability of the attacking carbocation and the nucleophilicity of the aryl moiety.Also, the behaviour of benzyl sulfones (29, 31a, and 32a) and sulfides (33, 34a and 36a) was inconsistent.Noteworthy, the Friedel-Crafts cyclization reaction is thus considered an accessible method for the synthesis of compounds 37-41 and 45, 51.