90401-82-4Relevant academic research and scientific papers
Tetrahydronaphthalene-derived amino alcohols and amino ketones as potent and selective inhibitors of the delayed rectifier potassium current I Ks
Ahmad, Saleem,Doweyko, Lidia,Ashfaq, Aaila,Ferrara, Francis N.,Bisaha, Sharon N.,Schmidt, Joan B.,DiMarco, John,Conder, Mary Lee,Jenkins-West, Tonya,Normandin, Diane E.,Russell, Anita D.,Smith, Mark A.,Levesque, Paul C.,Lodge, Nicholas J.,Lloyd, John,Stein, Philip D.,Atwal, Karnail S.
, p. 99 - 102 (2004)
Class III anti-arrhythmic drugs (e.g., dofetilide) prolong cardiac action potential duration (APD) by blocking the fast component of the delayed rectifier potassium current (IKr). The block of IKr can result in life threatening ventr
IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AS HISTONE DEMETHYLASE INHIBITORS
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Paragraph 0185, (2018/01/15)
This disclosure relates, inter alia, to compounds that inhibit histone demethylase activity. In particular, the disclosure relates to compounds that inhibit histone lysine demethylase KDM5B, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions disclosed herein.
Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models
Chen, Young K.,Bonaldi, Tiziana,Cuomo, Alessandro,Del Rosario, Joselyn R.,Hosfield, David J.,Kanouni, Toufike,Kao, Shih-Chu,Lai, Chon,Lobo, Neethan A.,Matuszkiewicz, Jennifer,McGeehan, Andrew,O'Connell, Shawn M.,Shi, Lihong,Stafford, Jeffrey A.,Stansfield, Ryan K.,Veal, James M.,Weiss, Michael S.,Yuen, Natalie Y.,Wallace, Michael B.
supporting information, p. 869 - 874 (2017/08/16)
Histone lysine demethylases (KDMs) play a vital role in the regulation of chromatin-related processes. Herein, we describe our discovery of a series of potent KDM4 inhibitors that are both cell permeable and antiproliferative in cancer models. The modulat
HISTONE DEMETHYLASE INHIBITORS
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Paragraph 00421; 00437, (2014/07/08)
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted amidopyridine or amidopyridazine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.
