904034-57-7Relevant academic research and scientific papers
An efficient magnetic copper ferrite nanoparticle: For one pot synthesis of 2-substituted benzoxazole via redox reactions
Sarode, Sachin A.,Bhojane, Jeevan M.,Nagarkar, Jayashree M.
, p. 206 - 210 (2015)
A new, green and sustainable approach for the synthesis of 2-substituted benzoxazole by using a one pot redox cascade condensation reaction of benzyl amine and 2-nitro phenol, catalysed by Cu Ferrite NPs is reported. Cu Ferrite NPs are magnetically separable, air stable and can be recycled up to fifth cycle without a significant loss in catalytic activity. The catalyst is characterised by FEG-SEM, TEM, EDAX and XRD.
Sequential one-pot synthesis of benzoxazoles from aryl bromides: Successive palladium- and copper-catalyzed reactions
Wu, Xiao-Feng,Neumann, Helfried,Neumann, Stephan,Beller, Matthias
supporting information, p. 3040 - 3042 (2013/06/27)
A convenient one-pot process has been developed for the synthesis of benzoxazoles. Starting from aryl bromides and 1,2-dibromobenzenes palladium-catalyzed aminocarbonylation and subsequent copper-catalyzed coupling reaction gave a variety of substituted benzoxazoles in moderate to good yields.
Palladium-catalyzed direct arylations of heteroarenes with tosylates and mesylates
Ackermann, Lutz,Althammer, Andreas,Fenner, Sabine
supporting information; experimental part, p. 201 - 204 (2009/04/10)
(Chemical Equation Presented) A toss up: A highly active palladium complex enabled the first direct arylation of heteroarenes through C-H bond functionalization using tosylates or mesylates as electrophiles with ample scope.
Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors
Johnson, Steven M.,Connelly, Stephen,Wilson, Ian A.,Kelly, Jeffery W.
, p. 260 - 270 (2008/09/18)
To develop potent transthyretin (TTR) amyloidogenesis inhibitors that also display high binding selectivity in blood, it proves useful to systematically optimize each of the three substructural elements that comprise a typical inhibitor: the two aryl rings and the linker joining them. In the first study, described herein, structural modifications to one aryl ring were evaluated by screening a library of 2-arylbenzoxazoles bearing thyroid hormone-like aryl substituents on the 2-aryl ring. Several potent and highly selective amyloidogenesis inhibitors were identified that exhibit minimal thyroid hormone nuclear receptor and COX-1 binding. High resolution crystal structures (1.3-1.5 ?) of three inhibitors (2f, 4f, and 4d) in complex with TTR were obtained to characterize their binding orientation. Collectively, the results demonstrate that thyroid hormone-like substitution patterns on one aryl ring lead to potent and highly selective TTR amyloidogenesis inhibitors that lack undesirable thyroid hormone receptor or COX-1 binding.
