90407-59-3

Basic information

• Product Name: 8-Indolizinecarboxylic acid, 1,2,3,5,6,7-hexahydro-, ethyl ester
• CAS NO: 90407-59-3
• Molecular Formula: C11H17NO2
• Molecular Weight: 195.261
• Mol File: 90407-59-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 8-Indolizinecarboxylic acid, 1,2,3,5,6,7-hexahydro-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Indolizinecarboxylic acid, 1,2,3,5,6,7-hexahydro-, ethyl ester(90407-59-3)
• EPA Substance Registry System: 8-Indolizinecarboxylic acid, 1,2,3,5,6,7-hexahydro-, ethyl ester(90407-59-3)

Safety Data

• Hazardous Substances Data: 90407-59-3(Hazardous Substances Data)

Upstream product

• 35150-22-2 (Z)-ethyl 2-(pyrrolidin-2-ylidene)acetate 
• 109-64-8 1,3-dibromo-propane 

Relevant articles and documents

Chemoselective intramolecular alkylation of the Blaise reaction intermediates: Tandem one-pot synthesis of exo -cyclic enaminoesters and their applications toward the synthesis of N -heterocyclic compounds

The intramolecular alkylative reactivity and N/C selectivity of the various Blaise reaction intermediates, which are formed from the reaction of the Reformatsky reagents with ω-chloroalkyl nitriles, did not reach the synthetic potential as an entry to exo-cyclic enaminoesters. To circumvent this issue, various additives were investigated, among which the addition of NaHMDS dramatically enhanced the reactivity and N/C selectivity. This modification provided a highly efficient route for the synthesis of various N-fused heterocyclic compounds, as it requires only two steps from nitriles.