90427-70-6Relevant articles and documents
Small peptides as modular catalysts for the direct asymmetric aldol reaction: Ancient peptides with aldolase enzyme activity
Zou, Weibiao,Ibrahem, Ismail,Dziedzic, Pawel,Sunden, Henrik,Cordova, Armando
, p. 4946 - 4948 (2007/10/03)
Simple peptides and their analogues having a primary amino group as the catalytic residue mediate the direct asymmetric intermolecular aldol reaction with high stereoselectivity and furnish the corresponding aldol products with up to 99% ee; this intrinsic ability of highly modular peptides may explain the initial molecular evolution of aldolase enzymes. The Royal Society of Chemistry 2005.