904286-72-2Relevant academic research and scientific papers
The pyroglutamate hydantoin rearrangement
Dieltiens, Nicolai,Claeys, Diederica D.,Zhdankin, Viktor V.,Nemykin, Victor N.,Allaert, Bart,Verpoort, Francis,Stevens, Christian V.
, p. 2649 - 2660 (2007/10/03)
When a mixture of a pyroglutamate and an isocyanate in THF is treated with NaH, a ring transformation occurs leading to functionalised hydantoins. The novel reaction involves a ring-closing ring-opening sequence providing a new and straightforward access
