90446-67-6Relevant articles and documents
Cell sugar transport channel inhibitor
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, (2021/07/24)
The invention discloses a cell sugar transport channel inhibitor of which the structure is shown as a formula (I). The cell sugar transport channel inhibitor disclosed by the invention can target a cell sugar transport channel, and inhibit tumor cell prol
Discovery of a new class of non-β-lactam inhibitors of penicillin-binding proteins with gram-positive antibacterial activity
O'Daniel, Peter I.,Peng, Zhihong,Pi, Hualiang,Testero, Sebastian A.,Ding, Derong,Spink, Edward,Leemans, Erika,Boudreau, Marc A.,Yamaguchi, Takao,Schroeder, Valerie A.,Wolter, William R.,Llarrull, Leticia I.,Song, Wei,Lastochkin, Elena,Kumarasiri, Malika,Antunes, Nuno T.,Espahbodi, Mana,Lichtenwalter, Katerina,Suckow, Mark A.,Vakulenko, Sergei,Mobashery, Shahriar,Chang, Mayland
, p. 3664 - 3672 (2014/03/21)
Infections caused by hard-to-treat methicillin-resistant Staphylococcus aureus (MRSA) are a serious global public-health concern, as MRSA has become broadly resistant to many classes of antibiotics. We disclose herein the discovery of a new class of non-β-lactam antibiotics, the oxadiazoles, which inhibit penicillin-binding protein 2a (PBP2a) of MRSA. The oxadiazoles show bactericidal activity against vancomycin-and linezolid-resistant MRSA and other Gram-positive bacterial strains, in vivo efficacy in a mouse model of infection, and have 100% oral bioavailability.
6-bromo-8-(4-[3H]methoxybenzamido)-4-oxo-4H-chromene-2- carboxylic acid: A powerful tool for studying orphan G protein-coupled receptor GPR35
Thimm, Dominik,Funke, Mario,Meyer, Anne,Müller, Christa E.
, p. 7084 - 7099 (2013/10/01)
The potent and selective GPR35 agonist 6-bromo-8-(4-methoxybenzamido)-4- oxo-4H-chromene-2-carboxylic acid (12) was obtained in tritium-labeled form, designated [3H]PSB-13253, with a specific activity of 36 Ci (1.33 TBq)/mmol. Radiolabeling was