90446-67-6

Upstream product

• 78324-14-8 tert-butyldimethylsilyl 4-((tert-butyldimethylsilyl)oxy)benzoate 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 99-96-7 4-hydroxy-benzoic acid 
• 83405-98-5 4-(tert-butyl-dimethylsilanyloxy)-benzoic acid 

Downstream Products

• 219603-30-2 (1R,2S)-(2-(4-((tert-butyldimethylsilyl)oxy)benzamido)-1-phenyl-1,3-propanediyl)bis(4-((tert-butyldimethylsilyl)oxy)benzoate) 
• 835873-00-2 4-(tert-butyldimethylsilanyloxy)-N-(2-iodophenyl)-N-methylbenzamide 
• 835873-12-6 [4-(tert-butyldimethylsilanyloxy)-benzoyl]-(4-ethoxy-2-iodophenyl)carbamic acid tert-butyl ester 
• 835873-01-3 4-(tert-butyldimethylsilanyloxy)-N-(2-iodo-4-methylphenyl)-N-methylbenzamide 
• 913985-85-0 [4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-(6,7-dimethoxy-1-methylene-3,4-dihydro-1H-isoquinolin-2-yl)-methanone 
• 913985-93-0 (7-allyloxy-5,6-dimethoxy-1-methylene-3,4-dihydro-1H-isoquinolin-2-yl)-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-methanone 
• 885053-28-1 C₁₈H₂₃NO₃Si 
• 1449688-61-2 C₂₀H₁₃⁽³⁾H₃BrNO₆ 
• 1450590-56-3 C₁₈H₉⁽³⁾H₃BrNO₆ 
• 1449688-60-1 C₂₅H₂₈BrNO₆Si 
• 1567711-31-2 5-(4-(tert-butyldimethylsilyloxy)phenyl)-3-(4-(4-(trifluoromethyl)phenoxy)-phenyl)-1,2,4-oxadiazole 
• 1567711-33-4 5-(4-(tert-butyldimethylsilyloxy)phenyl)-3-(4-phenoxyphenyl)-1,2,4-oxadiazole 
• 1136832-74-0 5-(4-(tert-butyldimethylsilyloxy)phenyl)-3-(4-phenoxyphenyl)-1,2,4-oxadiazole 
• 133642-20-3 4-(tert-butyldimethylsilanyloxy)benzoic acid methyl ester 

Relevant academic research and scientific papers

Cell sugar transport channel inhibitor

The invention discloses a cell sugar transport channel inhibitor of which the structure is shown as a formula (I). The cell sugar transport channel inhibitor disclosed by the invention can target a cell sugar transport channel, and inhibit tumor cell prol

Tumor diagnosis and treatment fluorescent probe for targeting tumor Wolburg effect

The invention discloses a tumor diagnosis and treatment fluorescent probe for targeting tumor Warburg effect, and the structure of the fluorescent probe is shown as a formula (I). The fluorescent probe can be directly used in a cell line to analyze and detect the expression degree of tumor cell GLUT1 protein, so as to complete the screening of tumor cells. Meanwhile, tumor cell proliferation is inhibited by directly blocking the GLUT1 channel to inhibit intake of sugar nutritional ingredients by tumors. And an effective means and a useful tool are provided for early screening and diagnosis oftumors, development of new anti-tumor drugs and the like.

Discovery of a new class of non-β-lactam inhibitors of penicillin-binding proteins with gram-positive antibacterial activity

Infections caused by hard-to-treat methicillin-resistant Staphylococcus aureus (MRSA) are a serious global public-health concern, as MRSA has become broadly resistant to many classes of antibiotics. We disclose herein the discovery of a new class of non-β-lactam antibiotics, the oxadiazoles, which inhibit penicillin-binding protein 2a (PBP2a) of MRSA. The oxadiazoles show bactericidal activity against vancomycin-and linezolid-resistant MRSA and other Gram-positive bacterial strains, in vivo efficacy in a mouse model of infection, and have 100% oral bioavailability.

Catalytic hydroamination of unactivated olefins using a Co catalyst for complex molecule synthesis

Functional group tolerance is one of the important requirements for chemical reactions, especially for the synthesis of complex molecules. Herein, we report a mild, general, and functional group tolerant intramolecular hydroamination of unactivated olefins using a Co(salen) complex, an N-fluoropyridinium salt, and a disiloxane reagent. This method, which was carried out at room temperature (or 0 °C), afforded three-, five-, six-, and seven-membered ring nitrogen-containing heterocyclic compounds and was compatible with diverse functional groups.

6-bromo-8-(4-[3H]methoxybenzamido)-4-oxo-4H-chromene-2- carboxylic acid: A powerful tool for studying orphan G protein-coupled receptor GPR35

The potent and selective GPR35 agonist 6-bromo-8-(4-methoxybenzamido)-4- oxo-4H-chromene-2-carboxylic acid (12) was obtained in tritium-labeled form, designated [3H]PSB-13253, with a specific activity of 36 Ci (1.33 TBq)/mmol. Radiolabeling was

STILBENES AND CHALCONES FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES

The present disclosure provides non-naturally occurring polyphenol compounds that upregulate the expression of Apolipoprotein A-I (ApoA-I). The disclosed compositions and methods can be used for treatment and prevention of cardiovascular disease and related disease states, including cholesterol or lipid related disorders, such as, e.g., atherosclerosis.

Synthesis and chiroptical properties of dendrimers elaborated from a chiral, nonracemic central core

Three generations of ester-terminated dendrimers have been constructed from (1R,2S)-2-amino-1-phenyl-1,3-propanediol, 1, as the central core. The chiroptical properties of the dendrimers were measured revealing that the molar rotations [Φ] of the dendrimers decreased with increasing dendrimer generation. Comparison to a series of substituted benzoate derivatives of 1 suggested that the decrease in rotation was a consequence of a steric effect upon the conformational equilibrium of the central core that increased with increasing dendrimer generation. The optical rotations of dendrimers 7-9 were also observed to be solvent and temperature dependent.