90446-71-2Relevant academic research and scientific papers
Hypochlorous acid fluorescent probe and preparation method thereof
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Paragraph 0026-0029, (2019/08/20)
The invention relates to the technical field of fluorescent probes, and in particular relates to a hypochlorous acid fluorescent probe and a preparation method thereof. The hypochlorous acid fluorescent probe provided by the invention has a molecular form
NEW ISOINDOLINE OR ISOQUINOLINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
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Page/Page column 47, (2015/02/19)
Compounds of formula (I): (I) wherein Het, R3, R4, R5, R7, R8, R9, T, p, p', q, and q' are as defined in the description are pro-apoptotic agents useful in the treatment of cancers and of a
Novel steroid mimics directed towards the estradiol skeleton
Bridgeman, Eve,Cavill, Julie L.,Schofield, Daniel J.,Wilkins, Derek S.,Tomkinson, Nicholas C. O.
, p. 8521 - 8524 (2007/10/03)
A series of non-symmetrical tri- and tetra-substituted ureas have been prepared to mimic the rigid tetracyclic core of estradiol. Tetra-substituted ureas were prepared by a five-step protocol, involving activation and displacement of a carbonyldiimidazole
Synthesis and antiarrhythmic and parasympatholytic properties of substituted phenols. 3. Modifications to the linkage region (region 3)
Stout,Matier,Barcelon-Yang,Reynolds,Brown
, p. 295 - 298 (2007/10/02)
As part of a continuing program of systematically modifying the structure of the class I antiarrhythmic drug changrolin, we synthesized 15 analogues in which the linkage between the two aromatic regions was altered. High antiarrhythmic activity and low parasympatholytic activity was found when the linkage region, designated region 3, contained a carbonyl moiety, including ketones, amides, and ureas. Secondary amides were superior to tertiary amides, while amide reversal resulted in no change in activities. One compound in this series, 2,6-bis(1-pyrrolidinyl-methyl)-4-benzamidophenol (ACC-9358), is undergoing preclinical evaluations.
