90450-01-4

Basic information

• Product Name: cyclopropylmethyl (12aS)-8-chloro-9-oxo-12,12a-dihydro-9H,11H-azeto[2,1-c]imidazo[1,5-a][1,4]benzodiazepine-1-carboxylate
• Synonyms: 9H,11H-Azeto(2,1-c)imidazo(1,5-a)(1,4)benzodiazepine-1-carboxylic acid, 8-chloro-12,12a-dihydro-9-oxo-, cyclopropylmethyl ester, (S)-
• CAS NO: 90450-01-4
• Molecular Formula: C₁₈H₁₆ClN₃O₃
• Molecular Weight: 357.7909
• Mol File: 90450-01-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 610.5°C at 760 mmHg
• Flash Point: 323°C
• Density: 1.65g/cm³
• Vapor Pressure: 7.56E-15mmHg at 25°C
• Refractive Index: 1.787
• CAS DataBase Reference: cyclopropylmethyl (12aS)-8-chloro-9-oxo-12,12a-dihydro-9H,11H-azeto[2,1-c]imidazo[1,5-a][1,4]benzodiazepine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: cyclopropylmethyl (12aS)-8-chloro-9-oxo-12,12a-dihydro-9H,11H-azeto[2,1-c]imidazo[1,5-a][1,4]benzodiazepine-1-carboxylate(90450-01-4)
• EPA Substance Registry System: cyclopropylmethyl (12aS)-8-chloro-9-oxo-12,12a-dihydro-9H,11H-azeto[2,1-c]imidazo[1,5-a][1,4]benzodiazepine-1-carboxylate(90450-01-4)

Safety Data

• Hazardous Substances Data: 90450-01-4(Hazardous Substances Data)

Upstream product

• 84378-02-9 ethyl (S)-8-chloro-12,12a-dihydro-9-oxo-9H,11H-azeto[2,1-c]imidazo[1,5-a][1,4]benzodiazepine-1-carboxylate 
• 2516-33-8 Cyclopropylmethanol 
• 2999-46-4 Ethyl isocyanoacetate 
• 84378-01-8 (S)-5-chloro-1,10a-dihydro-azeto[2,1-c][1,4]benzodiazepine-4,10-(2H,9H)-dione 

Relevant articles and documents

Imidazobenzodiazepines

There are described novel pharmaceutically active substances which have a pronounced affinity to the central benzodiazepine receptors and which have only a low toxicity.These active substances, namely imidazobenzodiazepines of the formula STR1 wherein A is lower alkylene, n is zero or 1, R 1 is lower alkynyl, lower alkenyl, aryl, (C 3-8)-cycloalkyl optionally substituted by lower alkyl or (C 5-8)-cycloalkenyl optionally substituted by lower alkyl, or a 5- or 6-membered saturated or unsaturated heterocycle which contains an oxygen or sulphur atom as a ring member and which is optionally substituted by lower alkyl, R 4 and R 5 each are hydrogen, halogen, trifluoromethyl, cyano, nitro, amino or lower alkyl and either R 2 is hydrogen and R 3 is lower alkyl or R 2 and R 3 together are dimethylene, trimethylene or propenylene, the compounds of formula I in which R 2 and R 3 together are dimethylene, trimethylene or propenylene having the (S) or (R,S) configuration with reference to the carbon atom denoted by γ,and their pharmaceutically acceptable acid addition salts, can be used as medicaments in the form of pharmaceutical preparations, especially in the control of convulsions and anxiety states and/or in the partial or complete antagonization of some or all activities which 1,4-benzodiazepines having tranquillizing activity or other substances display via the central benzodiazepine receptors.