904580-07-0Relevant academic research and scientific papers
Structure-based design of thienobenzoxepin inhibitors of PI3-kinase
Staben, Steven T.,Siu, Michael,Goldsmith, Richard,Olivero, Alan G.,Do, Steven,Burdick, Daniel J.,Heffron, Timothy P.,Dotson, Jenna,Sutherlin, Daniel P.,Zhu, Bing-Yan,Tsui, Vickie,Le, Hoa,Lee, Leslie,Lesnick, John,Lewis, Cristina,Murray, Jeremy M.,Nonomiya, Jim,Pang, Jodie,Prior, Wei Wei,Salphati, Laurent,Rouge, Lionel,Sampath, Deepak,Sideris, Steve,Wiesmann, Christian,Wu, Ping
, p. 4054 - 4058 (2011)
Starting from thienobenzopyran HTS hit 1, co-crystallization, molecular modeling and metabolic analysis were used to design potent and metabolically stable inhibitors of PI3-kinase. Compound 15 demonstrated PI3K pathway suppression in a mouse MCF7 xenogra
