904582-41-8Relevant academic research and scientific papers
Development of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureus
Lee, Kyungae,Campbell, Jennifer,Swoboda, Jonathan G.,Cuny, Gregory D.,Walker, Suzanne
supporting information; experimental part, p. 1767 - 1770 (2010/07/08)
A small molecule (1835F03) that inhibits Staphylococcus aureus wall teichoic acid biosynthesis, a proposed antibiotic target, has been discovered. Rapid, parallel, solution-phase synthesis was employed to generate a focused library of analogs, providing detailed information about structure-activity relationships and leading to the identification of targocil, a potent antibiotic.
